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Fig. 7 | Arthritis Research & Therapy

Fig. 7

From: High-throughput sequencing of CD4+ T cell repertoire reveals disease-specific signatures in IgG4-related disease

Fig. 7

Expression levels of CDR3 sequences associated with known antigen specificity according to McPAS-TCR database. a Heatmap presenting the frequencies of sequences associated with each disease in CD4+ T cell repertoire of each individual. b Boxplot summarizing the frequencies of sequences associated with each immune function in CD4+ T cell repertoire of healthy controls and IgG4-RD patients. Difference between the groups was analyzed by Welch’s t test (for the frequencies of sequences associated with pathogens, autoimmune, and cancer) or Mann-Whitney U test (for the frequencies of sequences associated with allergy). Analysis was performed on downsampled data

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