High-throughput sequencing of CD4+ T cell repertoire reveals disease-specific signatures in IgG4-related disease

Table 2 IgG4-RD-specific CDR3 amino acid sequences

CDR3 amino acid sequence	IgG4-RD patients with expanded clones	IgG4-RD patients with clones of lower frequencies
CASSSWTGGRYNSPLHF	PT-1, PT-6
CATSRRPGLEINNEQFF	PT-1, PT-8
CASSLSGTNEQFF	PT-1, PT-5
CASSPPGLDFSGANVLTF	PT-2, PT-7
CASSQGTGVRGTEAFF	PT-4, PT-5, PT-6	PT-1, PT-3, PT-7, PT-9
CSAPTGGNSGANVLTF	PT-4, PT-7	PT-5
CASSLTGTNTEAFF	PT-4, PT-8	PT-1, PT-3, PT-6
CASSFINEQFF	PT-4, PT-8
CASSLVSSGSNEQFF	PT-4, PT-5
CAIGQTYEQYF	PT-4, PT-7
CATSGFGSEQYF	PT-5, PT-6	PT-1, PT-4, PT-7, PT-8

Listed are the CDR3 amino acid sequences expanded in at least two IgG4-RD patients, while not detected in healthy controls (even at lower frequencies)

ISSN: 1478-6362