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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: Alterations of voluntary behavior in the course of disease progress and pharmacotherapy in mice with collagen-induced arthritis

Fig. 5

Influence of tofacitinib on CIA-associated changes in temperature preference (experiment 4). ac Time course of arthritis score (a), incidence of arthritis (b), and change in average hind paw thickness from day 19 (c) in tofacitinib-treated and vehicle-treated mice with CIA. The values are shown as the mean ± standard error of the mean. The interaction effects were significant (p < 0.05) by two-way repeated-measures ANOVA in b and c. *p < 0.05, **p < 0.01, tofacitinib vs. vehicle; by the Mann-Whitney U test (a), Student’s t test (b), and Welch’s t test (c). p < 0.01; by Friedman’s test (a) and one-way repeated-measures ANOVA (b, c). d Time-dependent change in preference ratio on day 42 in the tofacitinib-treated (filled circle) and vehicle-treated (open circle) CIA mice. The ordinate indicates the preference ratio per 2 min. The color scale above indicates the temperature of each plate at each time point. The horizontal dotted line indicates a preference ratio of 0.5. The values are shown as the mean ± standard error of the mean. *p < 0.05, **p < 0.01, tofacitinib vs. vehicle; Student’s t test. e Time course of preference ratio for phase II (mean 6–18 min) in tofacitinib-treated and vehicle-treated CIA mice. The values are shown as the mean ± standard error of the mean. *p < 0.05, tofacitinib vs. vehicle; by two-way repeated-measures ANOVA. f1 Scatter plots showing the relationship between the preference ratio in phase II (y axis) and the arthritis score (x axis) for tofacitinib-treated (below) and vehicle-treated (above) CIA mice. f2 The time course of the rank correlation coefficient between the preference ratio in phase II and the arthritis score in tofacitinib-treated (filled diamond) and vehicle-treated (open diamond) CIA mice. The hashed zone indicates the 95% confidence interval for Kendall’s tau. *p < 0.05, **p < 0.01, by Kendall’s correlation analysis. #p < 0.05, by the Z-transform method. CIA, collagen-induced arthritis; n.s., not significant

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