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Table 1 Characteristics of SSc patients

From: Complex assessment of bone mineral density, fracture risk, vitamin D status, and bone metabolism in Hungarian systemic sclerosis patients

CharacteristicsSSc (n = 44), mean ± SD or n (%)
Demographics and FRAX-related parameters
 Age (years)64.1 ± 9.0
 BMI (kg/m2)25.4 ± 3.9
 Patients in menopause31 (70.4)
 Menopausal age (years)46.1 ± 3.2
 Duration of menopause (years)21.5 ± 7.8
 Current smoking1 (2.2)
 Alcohol intake5 (11.3)
 History of fracture19 (43.2)
 Family history of hip fracture4 (9)
Disease characteristics
 Disease duration (years)18.0 ± 5.9
Type of disease
 Limited cutaneous33 (75)
 Diffuse cutaneous11 (25)
 Current digital ulcers13 (29.5)
Organ involvement
 Interstitial lung disease35 (79.5)
 Cardiac involvement29 (65.9)
 Pulmonary arterial hypertension3 (6.8)
 Dysphagia and esophageal reflux disease25 (56.8)
 Malabsorption syndrome13 (29.5)
Serological tests
 Antinuclear antibody (ANA) positivity33 (75)
 Anticentromere antibody (ACA) positivity7 (15.9)
 Anti-topoisomerase I antibody (Scl-70) positivity11 (25)
Treatment for SSc manifestations
 Corticosteroid (short-term)17 (38.6)
 Cyclophosphamide8 (18.1)
 Other immunosuppressive drugs (MTX, AZA)13 (29.5)
 Rituximab1 (2.2)
Treatment for OP
 Calcium supplementation32 (72.7)
 Vitamin D supplementation32 (72.7)
 Bisphosphonates16 (36.3)
 Denosumab2 (4.5)
  1. Abbreviations: AZA azathioprine, BMI body mass index, FRAX fracture risk assessment tool, MTX methotrexate. See text for further explanations