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Table 2 Bone turnover markers and bone status evaluated with DXA and pQCT in SSc patients and controls

From: Complex assessment of bone mineral density, fracture risk, vitamin D status, and bone metabolism in Hungarian systemic sclerosis patients

ParameterSSc (n = 44)Control (n = 33)p value
Bone turnover parameters
 Total calcium (mmol/L; mean ± SD)2.41 ± 0.142.32 ± 0.110.001
 PTH (pmol/L; mean ± SD)5.47 ± 2.844.14 ± 1.380.008
 OC (μg/L; mean ± SD)22.22 ± 9.5425.2 ± 7.760.075
 CTX-I (μg/L; mean ± SD)0.359 ± 0.1930.28 ± 0.20.051
 P1NP (μg/L; mean ± SD)49.38 ± 24.4743.2 ± 21.90.135
 25OH D (nmol/L; mean ± SD)53.96 ± 36.8053.46 ± 16.350.47
 25OH levels < 75 nmol/L (n; %)32 (73%)30 (91%)0.06
 25OH levels < 50 nmol/L (n; %)26 (60%)13 (39.3%)0.003
FRAX
 Hip fracture (%; mean ± SD)4.00 ± 4.362.31 ± 2.490.049
 Major fracture (%; mean ± SD)13.48 ± 8.039.28 ± 5.130.009
BMD
 Lumbar spine (L2–4; g/cm2; mean ± SD)0.880 ± 0.1080.996 ± 0.1810.019
 Femoral neck (FN; g/cm2; mean ± SD)0.786 ± 0.1340.91 ± 0.090.007
T-score
 Lumbar spine (L2–4; mean ± SD)− 1.64 ± 1.48− 0.50 ± 0.920.005
 Femoral neck (FN; mean ± SD)− 1.78 ± 1.01− 0.44 ± 0.84< 0.001
Femoral neck
 Osteoporosis (n; %)10 (22.7%)0 (0%)0.004
 Osteopenia (n; %)23 (52.2%)15 (45.4%)0.009
Lumbar spine
 Osteoporosis (n; %)10 (22.7%)0 (0%)0.004
 Osteopenia (n; %)16 (36.3%)19 (57.5%)0.106
Distal radius pQCT
 Total density (mg/cm3; mean ± SD)248.42 ± 70.94347.94 ± 40.16< 0.001
 Cortical density (mg/cm3; mean ± SD)328.03 ± 103.32487.06 ± 42.45< 0.001
 Trabecular density (mgcm3; mean ± SD)150.93 ± 61.91184.76 ± 33.030.037
  1. Abbreviations: BMD bone mineral density, CTX C-terminal telopeptides of type 1 collagen, D100 total volumetric BMD, Dcort volumetric cortical BMD, Dtrab volumetric trabecular BMD, FRAX fracture risk assessment tool, OC osteocalcin, P1NP total procollagen type I amino-terminal propeptide, pQCT peripheral quantitative computed tomography, PTH parathyroid hormone. See text for further explanations