Tissue | 50 mpk half-life—hours | 75 mpk half-life—hours |
---|
Plasma | 0.2566 | 0.47 |
Heart | 0.266 | 0.24 |
Spleen | 4.626 | N/A |
Tumor | 0.3676 | 0.1657 |
Muscle | 0.147 | 0.094 |
- Following intraperitoneal (i.p) injections of takinib (50/75 mpk), tissue takinib concentrations were evaluated at 0 h, 1 h, 2 h, 4 h, 8 h, 16 h, and 24 h. T½ reported in hours. Mpk milligrams per kilogram of body weight