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Table 1 Takinib pharmacokinetics in C3 tagged mice

From: Pharmacological inhibition of TAK1, with the selective inhibitor takinib, alleviates clinical manifestation of arthritis in CIA mice

Tissue50 mpk half-life—hours75 mpk half-life—hours
Plasma0.25660.47
Heart0.2660.24
Spleen4.626N/A
Tumor0.36760.1657
Muscle0.1470.094
  1. Following intraperitoneal (i.p) injections of takinib (50/75 mpk), tissue takinib concentrations were evaluated at 0 h, 1 h, 2 h, 4 h, 8 h, 16 h, and 24 h. T½ reported in hours. Mpk milligrams per kilogram of body weight