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Table 1 Takinib pharmacokinetics in C3 tagged mice

From: Pharmacological inhibition of TAK1, with the selective inhibitor takinib, alleviates clinical manifestation of arthritis in CIA mice

Tissue

50 mpk half-life—hours

75 mpk half-life—hours

Plasma

0.2566

0.47

Heart

0.266

0.24

Spleen

4.626

N/A

Tumor

0.3676

0.1657

Muscle

0.147

0.094

  1. Following intraperitoneal (i.p) injections of takinib (50/75 mpk), tissue takinib concentrations were evaluated at 0 h, 1 h, 2 h, 4 h, 8 h, 16 h, and 24 h. T½ reported in hours. Mpk milligrams per kilogram of body weight