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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Conferring extracellular matrix affinity enhances local therapeutic efficacy of anti-TNF-α antibody in a murine model of rheumatoid arthritis

Fig. 2

Binding of PlGF-2123-144-α-TNF to human cartilage. Unmodified α-TNF and PlGF-2123-144-α-TNF binding to fibronectin (Fn), decorin (DCN), collagen I (Col I), Col II, Col III, and Col IV were analyzed by ELISA (n = 3, mean + SE). *P < 0.05, compared with binding of unmodified α-TNF (Student’s t test). b Representative images of human osteoarthritis specimen probed with either unmodified α-TNF and PlGF-2123-144-α-TNF (red), anti-type II collagen antibody (blue), and anti-decorin antibody (green). Scale bar, 500 μm

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