Fig. 5
Effect of PlGF-2123-144-α-TNF locally injected around joints of the CAIA model. Arthritis was induced by intraperitoneal injection of anti-collagen antibodies, followed by intraperitoneal injection of LPS. On the day of LPS injection, isotype control IgG (100 μg), unmodified α-TNF (100 μg), or PlGF-2123-144-α-TNF (1 μg) was subcutaneously injected into the left hind paw of the CAIA mice. Arthritis scores of the treated paw and the untreated paw represent the mean ± SE from 8 mice. *P < 0.05, compared with the scores on day 6 of each group (Tukey’s multiple comparison test)