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Fig. 6 | Arthritis Research & Therapy

Fig. 6

From: Conferring extracellular matrix affinity enhances local therapeutic efficacy of anti-TNF-α antibody in a murine model of rheumatoid arthritis

Fig. 6

Effect of PlGF-2123-144-α-TNF in joint destruction of the arthritis model. Arthritis was induced by intraperitoneal injection of anti-collagen antibodies, followed by intraperitoneal injection of LPS. On the day of LPS injection, PlGF-2123-144-α-TNF (0.1 μg) was subcutaneously injected into the left hind paw of the CAIA mice. a Arthritis scores of the treated paw represent the mean ± SE from 4 mice. b Representative H&E image of joints on day 9 in the untreated control (left) and PlGF-2123-144-α-TNF-treated group (right). Arrows indicate cellular infiltrations. Scale bars, 200 μm

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