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Table 1 Clinical characteristics of systemic sclerosis patients and age- and sex-matched controls

From: High risk of gastrointestinal hemorrhage in patients with systemic sclerosis

 Case (n = 3665)Control (n = 18,325) 
N (%)N (%)p value
Age, years49.1 ± 14.949.1 ± 14.91
Sex
 Male760 (20.7)3800 (20.7)1
Comorbidity
 Diabetes mellitus374 (10.4)1090 (5.9)< 0.001
 Hypertension723 (20.0)2116 (11.5)< 0.001
 Dyslipidemia424 (11.7)829 (4.5)< 0.001
 Coronary artery disease339 (9.4)770 (4.2)< 0.001
 Chronic kidney disease121 (3.3)116 (0.6)< 0.001
 Chronic obstructive pulmonary disease461 (12.8)916 (5.0)< 0.001
 History of uncomplicated peptic ulcer disease262 (7.1)644 (3.5)< 0.001
Medications
 Antiplatelets491 (13.4)705 (3.8)< 0.001
 Warfarin45 (1.2)43 (0.2)< 0.001
 Traditional nonsteroidal anti-inflammatory drugs1250 (34.1)3015 (16.5)< 0.001
 Cyclooxygenase-2 inhibitors485 (13.2)100 (0.5)< 0.001
 Proton pump inhibitors155 (4.2)103 (0.6)< 0.001
 Histamine type 2 receptor antagonist101 (2.8)233 (1.3)< 0.001
 Steroids1370 (37.4)564 (3.1)< 0.001