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Table 1 Clinical characteristics of systemic sclerosis patients and age- and sex-matched controls

From: High risk of gastrointestinal hemorrhage in patients with systemic sclerosis

 

Case (n = 3665)

Control (n = 18,325)

 

N (%)

N (%)

p value

Age, years

49.1 ± 14.9

49.1 ± 14.9

1

Sex

 Male

760 (20.7)

3800 (20.7)

1

Comorbidity

 Diabetes mellitus

374 (10.4)

1090 (5.9)

< 0.001

 Hypertension

723 (20.0)

2116 (11.5)

< 0.001

 Dyslipidemia

424 (11.7)

829 (4.5)

< 0.001

 Coronary artery disease

339 (9.4)

770 (4.2)

< 0.001

 Chronic kidney disease

121 (3.3)

116 (0.6)

< 0.001

 Chronic obstructive pulmonary disease

461 (12.8)

916 (5.0)

< 0.001

 History of uncomplicated peptic ulcer disease

262 (7.1)

644 (3.5)

< 0.001

Medications

 Antiplatelets

491 (13.4)

705 (3.8)

< 0.001

 Warfarin

45 (1.2)

43 (0.2)

< 0.001

 Traditional nonsteroidal anti-inflammatory drugs

1250 (34.1)

3015 (16.5)

< 0.001

 Cyclooxygenase-2 inhibitors

485 (13.2)

100 (0.5)

< 0.001

 Proton pump inhibitors

155 (4.2)

103 (0.6)

< 0.001

 Histamine type 2 receptor antagonist

101 (2.8)

233 (1.3)

< 0.001

 Steroids

1370 (37.4)

564 (3.1)

< 0.001