Fig. 2

Differentially expressed genes and their functional networks. a Protein-protein interaction network of upregulated DEGs. Informative genes are colored and identified in the right-side table. b Functional enrichment map from the functional enrichment analysis using the Enrichr tool (https://amp.pharm.mssm.edu/Enrichr3/). Nodes represent gene ontology–biological process (GO-BP) gene sets, and GO-BPs of interest are labeled. Their color intensity and size are proportional to the enrichment score and the gene size, respectively. The edge thickness represents the degree of overlap between gene sets, and only edges with a Jaccard similarity coefficient larger than 0.25 are visualized. See Additional file 1: Figure S2 for the full node labels