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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: Integrated systems analysis of salivary gland transcriptomics reveals key molecular networks in Sjögren’s syndrome

Fig. 5

Temporal changes of molecular traits in SjS patients receiving rituximab therapy. a Temporal change of the cluster classification at baseline and 12 weeks later by treatment response. C1 and C2 indicate clusters 1 and 2, respectively, and the samples were classified according to the modeled Bayesian classifier. b Temporal change of the enrichment scores of the main SjS-relevant pathways at baseline and 12 weeks later by treatment response. c Temporal change of the enrichment scores of the main cell subsets at baseline and 12 weeks later by treatment response. Samples from the same patient are linked by a line. The red- and blue-colored dots indicate responders and non-responders, respectively. The difference between the two time points was tested by paired t test. *P < 0.05; **P < 0.01

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