Is 18F-FDG PET/CT useful for diagnosing relapsing polychondritis with airway involvement and monitoring response to steroid-based therapy?

Zeng, Yunxiang; Li, Minfang; Chen, Sheng; Lin, Lin; Li, Shiyue; He, Jianxing; Wang, Jinlin

doi:10.1186/s13075-019-2083-8

Table 1 Demographic characteristics of the 30 patients with RP

From: Is ¹⁸F-FDG PET/CT useful for diagnosing relapsing polychondritis with airway involvement and monitoring response to steroid-based therapy?

No.	Age (y)/sex	Chief complaint^a (duration; months)	Misdiagnosis	Serum levels			ANAs	Lung function			Chest CT scan^b	Biopsy site
No.	Age (y)/sex	Chief complaint^a (duration; months)	Misdiagnosis	ESR (mm/1 h)	CRP (mg/dL)	RF (IU/mL)	ANAs	FEV₁ (L)	FVC (L)	FEV₁/FVC (%)	Chest CT scan^b	Biopsy site
1	37/M	1 (6)	–	100	22.0	2.1	N	1.68	4.61	36.4	a, b	Tracheal (−)/nasal cartilage (+)
2	38/M	1, 2 (18)	Asthma	115	10.69	3.6	N	1.74	4.69	37.1	a, b	Tracheal (−)/auricular (+)
3	55/M	1, 3 (6)	–	10	0.03	2.4	N	2.57	3.32	77.3	c	Tracheal (−)/nasal cartilage (+)
4	66/F	1, 4 (24)	COPD	105	5.36	4.2	N	1.64	4.56	36.0	e	Tracheal (−)/auricular (+)
5	41/M	1, 4 (9)	–	120	26.41	2.0	N	0.92	1.32	69.7	a, b	Tracheal (−)/auricular (+)
6	55/M	1 (10)	–	112	23.41	2.8	N	1.32	4.19	31.46	a, b	Tracheal (−)/auricular (+)
7	64/M	5 (120)	COPD	11	0.88	4.9	N	0.57	2.37	31.7	a, b	Tracheal (−)/auricular (+)
8	60/M	4 (72)	Amyloidosis	23	1.02	3.4	N	0.49	3.37	92.3	a, b, c	Auricular (+)
9	42/M	1, 4, 6 (4)	–	87	16.2	2.5	N	1.43	4.08	35.0	a, b, c	Tracheal (−)/auricular (+)
10	47/F	1, 4, 7 (1)	–	45	21.0	3.1	N	2.30	4.02	46.5	b	Tracheal (−)/auricular (−)
11	50/F	1 (4); 4 (0.5)	–	34	6.4	3.0	N	1.10	3.67	30.0	b	Tracheal (−)/auricular (+)
12	44/F	1 (4); 4 (1)	Asthma	45	3.4	2.6	N	2.30	4.32	53.2	a, b	Tracheal (−)/auricular (+)
13	44/F	1, 5 (10)	Asthma	68	34.4	3.2	N	1.70	3.89	43.7	a, b	Tracheal (−)/auricular (+)
14	48/F	4 (132)	Asthma	34	10.0	1.0	N	0.67	2.33	28.8	a, b, c	Nasal cartilage (+)
15	25/M	1, 7 (1); 3 (0.5)	–	121	23.0	1.7	N	2.33	4.87	47.8	a, b	Tracheal (−)/auricular (+)
16	26/F	1, 4 (6)	Asthma	56	21.0	2.6	50 U/ml	1.02	3.24	31.5	a, b	Auricular (+)
17	52/M	1, 5, 7 (60)	Asthma	45	19.3	2.5	N	1.05	3.45	30.4	a, b	Auricular (+)
18	43/F	4 (6); 1, 5 (2)	–	34	12.0	1.3	N	2.00	4.01	49.9	a	Nasal cartilage (+)
19	36/F	1, 8 (12); 4, 7 (6)	–	36	11.7	2.6	48 U/ml	1.87	3.56	52.5	a, b	Tracheal (−)/auricular (+)
20	36/M	6 (12); 4 (6)	–	110	34.12	2.1	N	1.56	3.67	42.5	a, b, c	Tracheal (+)
21	42/M	1, 7 (60)	Asthma	34	12.8	1.8	N	2.30	4.50	51.1	a, b	Tracheal (−)/auricular (+)
22	45/M	1, 3 (7)	–	22	11.33	2.3	N	1.20	2.05	58.5	a, d	Auricular (+)
23	34/F	2, 4 (8)	–	56	23.0	3.5	N	1.98	2.87	69.0	a, b, d	Tracheal (−)
24	62/M	1, 7 (36)	COPD	45	21.02	2.5	N	1.56	3.45	45.2	a, b	Tracheal (−)/nasal cartilage (+)
25	45/F	1, 5 (17)	–	33	12.34	1.56	N	2.01	4.56	44.1	a	Tracheal (+)
26	34/F	2, 4 (9)	–	98	23.56	2.01	N	1.87	3.45	54.2	a, b	Tracheal (−)/auricular (+)
27	29/M	1, 3 (8)	–	121	26.71	2.76	N	1.23	3.56	34.6	a, c	Auricular (−)
28	45/M	1, 5 (14)	–	56	11.0	2.04	N	1.34	3.21	41.7	a, b, c	Tracheal (−)/auricular (+)
29	64/M	1, 4 (15)	Asthma	45	32.1	2.87	N	2.23	4.67	47.8	a, b	Tracheal (−)/auricular (+)
30	35/F	1, 6 (12)	–	36	23.1	3.45	N	0.97	1.89	51.3	a, b	Tracheal (−)/auricular (+)

Chief complaint: 1 = cough, 2 = chest pain, 3 = fever, 4 = shortness of the breath, 5 = wheezing, 6 = hoarseness, 7 = excessive sputum, 8 = pharyngalgia. Chest CT scan: a = diffuse thickening and narrowing of trachea, b = diffuse thickening and narrowing of main bronchus, c = calcification of the trachea, d = enlargement of the mediastinal lymph node, e = no abnormal manifestations
ANAs antinuclear antibodies, COPD chronic obstructive pulmonary disease, CRP C-reactive protein, ESR erythrocyte sedimentation rate, F female, FEV₁ forced expiratory volume in 1 s, FVC forced vital capacity, M male, N none, P present, RF rheumatoid factor, RP relapsing polychondritis, y years

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