Fig. 4From: Inhibition of Nrf2/HO-1 signaling leads to increased activation of the NLRP3 inflammasome in osteoarthritisHistological and microstructural changes in the subchondral bone of the superior articular surface in OA model rats. Representative images from experiments are shown. a Safranin O/fast green-stained sections of the subchondral bone of the tibia. The damaged region of the articular surface is indicated by black arrows. Scale bar = 200 μm. b 2D imaging of the structure of the subchondral bone of the tibia. The damaged region of the articular surface is indicated by white arrows. c 3D imaging of the medial compartment of the subchondral bone of the tibia. Scale bar = 1.0 mm. d Quantitative results based on the OARSI scoring system. e, f Quantitative results of the structural parameters of the tibial subchondral bone, including BV/TV (trabecular BV per TV) and BMD (n = 8, *P < 0.05, **P < 0.01 vs sham)Back to article page