Table 4 HDISS-DU score responsiveness
Response category | Response type | Number | LS mean change in HDISS-DU score† (SE) | Overall F test value | p value | Effect size |
|---|---|---|---|---|---|---|
Patient-reported severity score | 18.04 | < 0.0001 | ||||
− 6 | Improvement | 1 | − 1.86 (0.72) | N/A | ||
− 5 | Improvement | 5 | − 1.41 (0.32) | − 1.3 | ||
− 4 | Improvement | 14 | − 0.94 (0.19) | − 0.9 | ||
− 3 | Improvement | 52 | − 0.66 (0.10) | − 0.6 | ||
− 2 | Improvement | 73 | − 0.59 (0.08) | − 0.5 | ||
− 1 | Improvement | 114 | − 0.22 (0.07) | − 0.2 | ||
0 | No change | 107 | − 0.03 (0.07) | 0.0 | ||
1 | Deterioration | 41 | 0.33 (0.11) | 0.3 | ||
2 | Deterioration | 7 | 0.36 (0.27) | 0.5 | ||
3 | Deterioration | 3 | 0.87 (0.42) | 0.7 | ||
4 | Deterioration | 2 | 0.59 (0.51) | 5.1 | ||
5 | Deterioration | N/A | N/A | N/A | ||
Physician-reported severity score | 13.99 | < 0.0001 | ||||
− 6 | Improvement | 2 | − 0.66 (0.53) | − 2.2 | ||
− 5 | Improvement | 1 | 0.18 (0.75) | N/A | ||
− 4 | Improvement | 9 | − 0.99 (0.25) | − 1.1 | ||
− 3 | Improvement | 46 | − 0.56 (0.11) | − 0.5 | ||
− 2 | Improvement | 90 | − 0.47 (0.08) | − 0.4 | ||
− 1 | Improvement | 124 | − 0.30 (0.07) | − 0.3 | ||
0 | No change | 129 | − 0.02 (0.07) | − 0.0 | ||
1 | Deterioration | 25 | 0.11 (0.15) | 0.2 | ||
2 | Deterioration | 7 | 1.09 (0.28) | 0.8 | ||
3 | Deterioration | 2 | 0.63 (0.53) | 0.6 | ||
4 | Deterioration | N/A | N/A | N/A | ||
5 | Deterioration | 1 | 0.29 (0.75) | N/A | ||
Patient-reported global change score | 28.25 | < 0.0001 | ||||
1 | Deterioration | 7 | 0.58 (0.27) | 0.4 | ||
2 | Deterioration | 18 | 0.72 (0.17) | 0.6 | ||
3 | Deterioration | 33 | 0.18 (0.13) | 0.2 | ||
4 | No change | 78 | 0.02 (0.08) | 0.0 | ||
5 | Improvement | 111 | − 0.25 (0.07) | − 0.3 | ||
6 | Improvement | 132 | − 0.53 (0.06) | − 0.5 | ||
7 | Improvement | 40 | − 0.86 (0.11) | − 0.8 | ||
Physician-reported global change score | 23.56 | < 0.0001 | ||||
1 | Deterioration | 3 | 1.18 (0.43) | 6.3 | ||
2 | Deterioration | 21 | 0.55 (0.16) | 0.4 | ||
3 | Deterioration | 40 | 0.10 (0.12) | 0.2 | ||
4 | No change | 65 | − 0.08 (0.09) | − 0.0 | ||
5 | Improvement | 122 | − 0.17 (0.07) | − 0.2 | ||
6 | Improvement | 13 | − 0.49 (0.07) | − 0.4 | ||
7 | Improvement | 55 | − 0.63 (0.10) | − 0.7 | ||
Responder status | 79.22 | < 0.0001 | ||||
Responder‡ | Improvement | 169 | − 0.65 (0.06) | − 0.6 | ||
Non-responder§ | No change | 251 | 0.01 (0.05) | 0.0 | ||