Psychometric validation of the Hand Disability in Systemic Sclerosis-Digital Ulcers (HDISS-DU®) patient-reported outcome instrument

Table 5 HDISS-DU score: anchor-based approach to identify a minimal meaningful change threshold

Measure	Anchor	Anchor response type	Number	Mean change in HDISS-DU score from baseline (SD)
Patient-reported severity	Improvement of less than one category	Less than minimal improvement	160	0.15 (0.70)
	Improvement of one category	Minimal improvement	114	− 0.25 (0.71)
	Improvement of more than one category	Greater than minimal improvement	145	− 0.71 (0.94)
Physician-reported severity	Improvement of less than one category	Less than minimal improvement	164	0.07 (0.75)
	Improvement of one category	Minimal improvement	124	− 0.29 (0.85)
	Improvement of more than one category	Greater than minimal improvement	148	− 0.55 (0.89)
Patient-reported global change	‘Minimally worse’	Minimal deterioration	33	0.19 (0.84)
Patient-reported global change	‘Minimally improved’	Minimal improvement	132	− 0.50 (0.85)
Physician-reported global change	‘Minimally worse’	Minimal deterioration	40	0.18 (0.76)
Physician-reported global change	‘Minimally improved’	Minimal improvement	130	− 0.50 (0.86)

Anchors and change in HDISS-DU score use week 16 data. A negative mean change in HDISS-DU score indicates an improvement
HDISS-DU Hand Disability in Systemic Sclerosis-Digital Ulcers, n number of participants, SD standard deviation

ISSN: 1478-6362