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Table 5 HDISS-DU score: anchor-based approach to identify a minimal meaningful change threshold

From: Psychometric validation of the Hand Disability in Systemic Sclerosis-Digital Ulcers (HDISS-DU®) patient-reported outcome instrument

MeasureAnchorAnchor response typeNumberMean change in HDISS-DU score from baseline (SD)
Patient-reported severityImprovement of less than one categoryLess than minimal improvement1600.15 (0.70)
Improvement of one categoryMinimal improvement114− 0.25 (0.71)
Improvement of more than one categoryGreater than minimal improvement145− 0.71 (0.94)
Physician-reported severityImprovement of less than one categoryLess than minimal improvement1640.07 (0.75)
Improvement of one categoryMinimal improvement124− 0.29 (0.85)
Improvement of more than one categoryGreater than minimal improvement148− 0.55 (0.89)
Patient-reported global change‘Minimally worse’Minimal deterioration330.19 (0.84)
‘Minimally improved’Minimal improvement132− 0.50 (0.85)
Physician-reported global change‘Minimally worse’Minimal deterioration400.18 (0.76)
‘Minimally improved’Minimal improvement130− 0.50 (0.86)
  1. Anchors and change in HDISS-DU score use week 16 data. A negative mean change in HDISS-DU score indicates an improvement
  2. HDISS-DU Hand Disability in Systemic Sclerosis-Digital Ulcers, n number of participants, SD standard deviation