Skip to main content

Table 2 Baseline characteristics of patients with IgG4-RD grouped by cluster analysis

From: Identifying clinical subgroups in IgG4-related disease patients using cluster analysis and IgG4-RD composite score

  Cluster 1
n = 20
Cluster 2
n = 68
Cluster 3
n = 66
p value
Sex (male; female) 2.33:1 3.533:1 0.94:1 0.002
Age (years) 54.3 ± 12.24 55.07 ± 14.66 51.29 ± 11.63 0.237
Disease duration (months) 12 (7, 24) 6 (2, 22.5) 12 (6, 36) 0.667
IgG4-RD RI 12.5 (10, 18.25) 12 (7, 15) 11 (7, 15) 0.203
Allergy history, n (%) 5 (25%) 33 (48.53%) 30 (45.45%) 0.17
Number of total organs involved 3 (2, 4.75) 3 (2, 4) 3 (2, 4) 0.3
Number of internal organs 2 (1, 2) 2 (1, 2.75) 0 (0, 1) < 0.001
Number of superficial organs 1 (0, 2) 0 (0, 2) 2 (1, 3) < 0.001
Internal organs ratio 0.41 (0.33, 0.67) 0.67 (0.5, 1) 0 (0, 0.25) < 0.001
Laboratory test at baseline
 WBC (×109/L) 7.93 (5.72, 8.33) 7.03 (5.86, 8.36) 6.09 (5.37, 7.03) 0.002
 Eosinophils (×109/L) 0.35 (0.11, 0.69) 0.23 (0.09, 0.45) 0.23 (0.14, 0.37) 0.615
 Eosinophils (%) 3.45 (1.43, 7.45) 3.15 (1.25, 5.95) 3.4 (1.98, 6.53) 0.836
 Lymphocyte (×109/L) 2.05 (1.78, 2.51) 2.09 (1.55, 2.58) 1.70 (1.54, 2.27) 0.091
 Lymphocyte (%) 29.24 (23.30, 33.79) 30.29 (22.16, 36.20) 30.73 (25.34, 36.82) 0.667
 Hemoglobin(g/L) 115 (98, 125) 138 (125.25, 149) 140.5 (131, 153.75) < 0.001
 Plt (×109/L) 303 (227.5, 386.75) 242 (180.5, 277.75) 232 (206, 282) 0.001
 ESR (mm/h) 97 (80.5, 112.75) 22 (7.25, 41.5) 11 (5, 25) < 0.001
 CRP (mg/L) 44.54 (5.01, 78.37) 2.64 (0.74, 9.61) 1.19 (0.36, 3.73) < 0.001
 IgG (g/L) 39.77 (24.48, 47.84) 18.40 (14.74, 23.43) 17.53 (13.87, 21.40) < 0.001
 IgA (g/L) 2.74 (0.85, 5.02) 2.23 (1.59, 2.84) 1.79 (1.33, 2.34) 0.087
 IgM (g/L) 0.88 (0.47, 1.57) 0.87 (0.58, 1.17) 0.90 (0.58, 1.41) 0.48
 IgG1 (mg/L) 15,100 (12,125, 29,900) 9175 (7242.5, 11,000) 8750 (7290, 10,200) < 0.001
 IgG2 (mg/L) 7455 (5127.5, 9942.5) 6560 (5060, 8575) 5535 (4415, 6962.5) 0.021
 IgG3 (mg/L) 1035 (590.25, 2240) 289.5 (195, 662) 422.5 (263, 711.5) < 0.001
 IgG4 (mg/L) 12,550 (2860, 52,975) 8535 (3085, 14,250) 7895 (4235, 14,725) 0.261
 IgE (kU/L) 546.5 (163.25, 1340.5) 275 (151.75, 855.75) 369 (99.2, 632.25) 0.183
 C3 (g/L) 0.88 (0.39, 1.51) 1.03 (0.86, 1.19) 0.95 (0.75, 1.04) 0.077
 C4 (g/L) 0.14 (0.03, 0.20) 0.20 (0.12, 0.27) 0.17 (0.13, 0.21) 0.03
 IgG4-RD CS 1.13 (0.37, 1.31) − 0.06 (− 0.43, 0.26) − 0.22 (− 0.48, − 0.08) < 0.001
  1. The continuous normally distributed data are presented as mean ± standard deviation; non-normally distributed data are presented as median (first quartile, third quartile)