Table 2 Baseline characteristics of patients with IgG4-RD grouped by cluster analysis
Cluster 1 n = 20 | Cluster 2 n = 68 | Cluster 3 n = 66 | p value | |
|---|---|---|---|---|
Sex (male; female) | 2.33:1 | 3.533:1 | 0.94:1 | 0.002 |
Age (years) | 54.3 ± 12.24 | 55.07 ± 14.66 | 51.29 ± 11.63 | 0.237 |
Disease duration (months) | 12 (7, 24) | 6 (2, 22.5) | 12 (6, 36) | 0.667 |
IgG4-RD RI | 12.5 (10, 18.25) | 12 (7, 15) | 11 (7, 15) | 0.203 |
Allergy history, n (%) | 5 (25%) | 33 (48.53%) | 30 (45.45%) | 0.17 |
Number of total organs involved | 3 (2, 4.75) | 3 (2, 4) | 3 (2, 4) | 0.3 |
Number of internal organs | 2 (1, 2) | 2 (1, 2.75) | 0 (0, 1) | < 0.001 |
Number of superficial organs | 1 (0, 2) | 0 (0, 2) | 2 (1, 3) | < 0.001 |
Internal organs ratio | 0.41 (0.33, 0.67) | 0.67 (0.5, 1) | 0 (0, 0.25) | < 0.001 |
Laboratory test at baseline | ||||
WBC (×109/L) | 7.93 (5.72, 8.33) | 7.03 (5.86, 8.36) | 6.09 (5.37, 7.03) | 0.002 |
Eosinophils (×109/L) | 0.35 (0.11, 0.69) | 0.23 (0.09, 0.45) | 0.23 (0.14, 0.37) | 0.615 |
Eosinophils (%) | 3.45 (1.43, 7.45) | 3.15 (1.25, 5.95) | 3.4 (1.98, 6.53) | 0.836 |
Lymphocyte (×109/L) | 2.05 (1.78, 2.51) | 2.09 (1.55, 2.58) | 1.70 (1.54, 2.27) | 0.091 |
Lymphocyte (%) | 29.24 (23.30, 33.79) | 30.29 (22.16, 36.20) | 30.73 (25.34, 36.82) | 0.667 |
Hemoglobin(g/L) | 115 (98, 125) | 138 (125.25, 149) | 140.5 (131, 153.75) | < 0.001 |
Plt (×109/L) | 303 (227.5, 386.75) | 242 (180.5, 277.75) | 232 (206, 282) | 0.001 |
ESR (mm/h) | 97 (80.5, 112.75) | 22 (7.25, 41.5) | 11 (5, 25) | < 0.001 |
CRP (mg/L) | 44.54 (5.01, 78.37) | 2.64 (0.74, 9.61) | 1.19 (0.36, 3.73) | < 0.001 |
IgG (g/L) | 39.77 (24.48, 47.84) | 18.40 (14.74, 23.43) | 17.53 (13.87, 21.40) | < 0.001 |
IgA (g/L) | 2.74 (0.85, 5.02) | 2.23 (1.59, 2.84) | 1.79 (1.33, 2.34) | 0.087 |
IgM (g/L) | 0.88 (0.47, 1.57) | 0.87 (0.58, 1.17) | 0.90 (0.58, 1.41) | 0.48 |
IgG1 (mg/L) | 15,100 (12,125, 29,900) | 9175 (7242.5, 11,000) | 8750 (7290, 10,200) | < 0.001 |
IgG2 (mg/L) | 7455 (5127.5, 9942.5) | 6560 (5060, 8575) | 5535 (4415, 6962.5) | 0.021 |
IgG3 (mg/L) | 1035 (590.25, 2240) | 289.5 (195, 662) | 422.5 (263, 711.5) | < 0.001 |
IgG4 (mg/L) | 12,550 (2860, 52,975) | 8535 (3085, 14,250) | 7895 (4235, 14,725) | 0.261 |
IgE (kU/L) | 546.5 (163.25, 1340.5) | 275 (151.75, 855.75) | 369 (99.2, 632.25) | 0.183 |
C3 (g/L) | 0.88 (0.39, 1.51) | 1.03 (0.86, 1.19) | 0.95 (0.75, 1.04) | 0.077 |
C4 (g/L) | 0.14 (0.03, 0.20) | 0.20 (0.12, 0.27) | 0.17 (0.13, 0.21) | 0.03 |
IgG4-RD CS | 1.13 (0.37, 1.31) | − 0.06 (− 0.43, 0.26) | − 0.22 (− 0.48, − 0.08) | < 0.001 |