Skip to main content

Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Table 2 Baseline characteristics of patients with IgG4-RD grouped by cluster analysis

From: Identifying clinical subgroups in IgG4-related disease patients using cluster analysis and IgG4-RD composite score

 Cluster 1
n = 20
Cluster 2
n = 68
Cluster 3
n = 66
p value
Sex (male; female)2.33:13.533:10.94:10.002
Age (years)54.3 ± 12.2455.07 ± 14.6651.29 ± 11.630.237
Disease duration (months)12 (7, 24)6 (2, 22.5)12 (6, 36)0.667
IgG4-RD RI12.5 (10, 18.25)12 (7, 15)11 (7, 15)0.203
Allergy history, n (%)5 (25%)33 (48.53%)30 (45.45%)0.17
Number of total organs involved3 (2, 4.75)3 (2, 4)3 (2, 4)0.3
Number of internal organs2 (1, 2)2 (1, 2.75)0 (0, 1)< 0.001
Number of superficial organs1 (0, 2)0 (0, 2)2 (1, 3)< 0.001
Internal organs ratio0.41 (0.33, 0.67)0.67 (0.5, 1)0 (0, 0.25)< 0.001
Laboratory test at baseline
 WBC (×109/L)7.93 (5.72, 8.33)7.03 (5.86, 8.36)6.09 (5.37, 7.03)0.002
 Eosinophils (×109/L)0.35 (0.11, 0.69)0.23 (0.09, 0.45)0.23 (0.14, 0.37)0.615
 Eosinophils (%)3.45 (1.43, 7.45)3.15 (1.25, 5.95)3.4 (1.98, 6.53)0.836
 Lymphocyte (×109/L)2.05 (1.78, 2.51)2.09 (1.55, 2.58)1.70 (1.54, 2.27)0.091
 Lymphocyte (%)29.24 (23.30, 33.79)30.29 (22.16, 36.20)30.73 (25.34, 36.82)0.667
 Hemoglobin(g/L)115 (98, 125)138 (125.25, 149)140.5 (131, 153.75)< 0.001
 Plt (×109/L)303 (227.5, 386.75)242 (180.5, 277.75)232 (206, 282)0.001
 ESR (mm/h)97 (80.5, 112.75)22 (7.25, 41.5)11 (5, 25)< 0.001
 CRP (mg/L)44.54 (5.01, 78.37)2.64 (0.74, 9.61)1.19 (0.36, 3.73)< 0.001
 IgG (g/L)39.77 (24.48, 47.84)18.40 (14.74, 23.43)17.53 (13.87, 21.40)< 0.001
 IgA (g/L)2.74 (0.85, 5.02)2.23 (1.59, 2.84)1.79 (1.33, 2.34)0.087
 IgM (g/L)0.88 (0.47, 1.57)0.87 (0.58, 1.17)0.90 (0.58, 1.41)0.48
 IgG1 (mg/L)15,100 (12,125, 29,900)9175 (7242.5, 11,000)8750 (7290, 10,200)< 0.001
 IgG2 (mg/L)7455 (5127.5, 9942.5)6560 (5060, 8575)5535 (4415, 6962.5)0.021
 IgG3 (mg/L)1035 (590.25, 2240)289.5 (195, 662)422.5 (263, 711.5)< 0.001
 IgG4 (mg/L)12,550 (2860, 52,975)8535 (3085, 14,250)7895 (4235, 14,725)0.261
 IgE (kU/L)546.5 (163.25, 1340.5)275 (151.75, 855.75)369 (99.2, 632.25)0.183
 C3 (g/L)0.88 (0.39, 1.51)1.03 (0.86, 1.19)0.95 (0.75, 1.04)0.077
 C4 (g/L)0.14 (0.03, 0.20)0.20 (0.12, 0.27)0.17 (0.13, 0.21)0.03
 IgG4-RD CS1.13 (0.37, 1.31)− 0.06 (− 0.43, 0.26)− 0.22 (− 0.48, − 0.08)< 0.001
  1. The continuous normally distributed data are presented as mean ± standard deviation; non-normally distributed data are presented as median (first quartile, third quartile)