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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: The protective role of the 3-mercaptopyruvate sulfurtransferase (3-MST)-hydrogen sulfide (H2S) pathway against experimental osteoarthritis

Fig. 5

Proposed mechanism for 3-MST involvement in osteoarthritic joints. Firstly, reactive oxygen species such as H2O2 decrease 3-MST expression (Fig. 4a). 3-MST inhibition leads to decreased endogenous H2S production (Fig. 3c) which favors increased chondrocyte calcification (Fig. 3a and d), and interleukin-6 secretion (Fig. 3b). An amplification loop exists between mineralization and interleukin-6, which triggers OA progression [9]. Finally, mineralization and interleukin-6 can also cause downregulation of 3-MST, leading to sustained deleterious signal towards disease progression

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