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Table 2 Association of HLA alleles with susceptibility to ankylosing spondylitis (P < 0.05 in conditional analysis on HLA-B27)

From: MHC associations of ankylosing spondylitis in East Asians are complex and involve non-HLA-B27 HLA contributions

SNP

FRQ

OR

P

P_con_B27

P_con_B27_B40

2-digit HLA alleles

HLA-C*15

0.04

1.01

0.97

9.30 × 10−19

9.88 × 10−17

HLA-DQB1*04

0.07

0.96

0.68

5.98 × 10−7

1.86 × 10−6

HLA-DRB1*13

0.07

0.37

6.28 × 10−15

2.53 × 10−4

7.85 × 10−4

HLA-B*40

0.12

0.58

2.63 × 10−11

2.54 × 10−4

NA

HLA-C*03

0.20

0.43

9.19 × 10−33

6.08 × 10−4

9.92 × 10−5

HLA-DQB1*06

0.22

0.52

1.50 × 10−20

6.32 × 10−4

1.25 × 10−3

HLA-B*53

0.00

0.62

0.46

7.33 × 10−4

2.87 × 10−4

HLA-B*38

0.01

2.10

0.041

9.55 × 10−4

3.35 × 10−4

HLA-C*05

0.01

0.25

2.75 × 10−3

1.77 × 10−3

2.68 × 10−3

HLA-B*15

0.10

0.40

1.13 × 10−21

0.021

0.082

HLA-DRB1*04

0.15

1.09

0.26

0.028

0.032

HLA-DPB1*45

0.00

0.98

0.97

0.029

0.025

HLA-DQA1*06

0.06

4.09

3.05 × 10−17

0.048

0.035

4-digit HLA alleles

HLA-C*1502

0.03

1.15

0.37

6.78 × 10−23

4.10 × 10−20

HLA-B*4002

0.03

0.79

0.16

9.55 × 10−12

6.54 × 10−8

HLA-DRB1*0405

0.06

0.93

0.51

2.30 × 10−7

1.06 × 10−6

HLA-DQB1*0401

0.05

0.90

0.45

5.05 × 10−6

1.54 × 10−5

HLA-B*4005

0.00

1.72

0.55

4.21 × 10−4

2.09 × 10−3

HLA-B*5301

0.00

0.62

0.46

7.20 × 10−4

2.82 × 10−4

HLA-DRB1*1302

0.05

0.37

5.63 × 10−13

1.13 × 10−3

2.88 × 10−3

HLA-B*3802

0.01

2.29

0.036

2.16 × 10−3

1.01 × 10−3

HLA-C*0501

0.00

0.38

0.054

3.98 × 10−3

5.60 × 10−3

HLA-DQA1*0102

0.27

0.36

3.45 × 10−30

4.68 × 10−3

0.013

HLA-B*4446

0.03

0.21

5.69 × 10−14

6.15 × 10−3

0.012

HLA-C*0304

0.08

0.53

1.72 × 10−9

0.012

6.95 × 10−5

HLA-DRB1*1501

0.08

0.56

5.36 × 10−8

0.022

0.024

HLA-B*4402

0.00

0.30

0.13

0.027

0.033

HLA-DPB1*4501

0.00

0.97

0.96

0.029

0.024

HLA-DQB1*0603

0.01

0.41

2.55 × 10−3

0.036

0.055

HLA-B*1501

0.04

0.24

2.94 × 10−15

0.047

0.11

HLA-DQA1*0601

0.06

4.09

3.04 × 10−17

0.048

0.035

HLA-B*5502

0.02

0.28

9.64 × 10−6

0.050

0.10

  1. OR odds ratio in unconditional analysis, FRQ allele frequency in controls, P P value in unconditional analysis, P_con_B27 P value in conditional analysis controlling HLA-B*27, P_con_B27_B40 P value in conditional analysis controlling HLA-B*27 and HLA-B*40