Fig. 3
From: Inhibition of effector B cells by ibrutinib in systemic sclerosis
Ibrutinib-mediated inhibition of the transcription factor NFκB. PBMCs of patients with SSc (n = 4) were treated with ibrutinib and stimulated with CpG (0.1 μM) for 24 h; DMSO (0.1%) was used as control. Phosphorylated NFκB (Ser536) was stained after methanol permeabilization. a Levels of pNFκB (MFI) are reduced significantly by ibrutinib. Bars depict the mean. Error bars represent SEM. *p < 0.05. b Representative histograms from one individual SSc patient