28 gene IRG score | Other IRG scores in JDM | ||||
---|---|---|---|---|---|
Assessment (n = 57) (range or upper limit of normal (ULN)) | JDM overall median, IQR | JDM overall (n = 57) | Anti-TIF1 Ab (n = 20)* | Bilgic et al. score‡ [6] | Greenberg et al. score§ [7] |
28 IRG score (n = 57) | 40.0 [1.8–236.0] | 40.0 [1.8–236.0] | 41.7 [−4.4–174.2] | 0.96** | 0.99** |
Physician global activity (0–10 VAS, n = 56) | 2.2 [1.5–3.7] | 0.39|| | 0.31 | 0.42|| | 0.39|| |
Total MMT (0–260, n = 36) | 242 [228–252] | − 0.36§ | − 0.13 | − 0.38§ | − 0.33 |
CMAS (0–52, n = 38) | 43 [37–48] | − 0.26 | − 0.22 | − 0.21 | − 0.18 |
CHAQ/HAQ (0–3.0, n = 42) | 0.75 [0.25–1.375] | 0.28 | 0.23 | 0.24 | 0.30 |
MDAAT (0–10 VAS, n = 39) | |||||
Muscle | 2.0 [1.0–2.9] | 0.31 | 0.29 | 0.40§ | 0.30 |
Constitutional | 1.3 [0.3–3.3] | 0.09 | 0.21 | 0.09 | 0.11 |
Cutaneous | 2.4 [1.1–3.8] | 0.29 | 0.62§ | 0.33§ | 0.30 |
Pulmonary | 0.6 [0.0–1.4] | 0.23 | 0.44 | 0.29 | 0.21 |
Skeletal (joint) | 0.9 [0.0–2.1] | 0.35§ | − 0.12 | 0.42|| | 0.36§ |
Extra-muscular activity | 1.9 [1.2–3.2] | 0.47|| | 0.76|| | 0.53¶ | 0.48|| |
(0–10 VAS, n = 40) | |||||
Disease Activity Score (0–20, n = 39) | 11 [9–13] | 0.33§ | 0.58§ | 0.35§ | 0.33§ |
DAS skin (0–9, n = 40) | 6 [5–7] | 0.16 | 0.73|| | 0.18 | 0.19 |
DAS muscle (0–11, n = 39) | 5 [3.75–7] | 0.25 | 0.24 | 0.26 | 0.23 |
Muscle enzymes (U/L) | |||||
CK (ULN 252 U/L, n = 56) | 90 [52–170] | −0.09 | − 0.18 | − 0.11 | − 0.07 |
Aldolase (ULN 7 U/L, n = 54) | 7.5 [5.8–10.1] | 0.24 | 0.18 | 0.25 | 0.24 |
AST (ULN 34 U/L, n = 56) | 24 [18–33] | 0.42|| | 0.24 | 0.38|| | 0.43¶ |
LDH (ULN 226 U/L, n = 56) | 186 [161–214] | 0.41|| | 0.27 | 0.39|| | 0.39|| |
Physician global damage (0–10, n = 46) | 1.0 [0.4–2.0] | −0.05 | 0.04 | −0.09 | − 0.05 |
MDI total damage (0–110, n = 34) | 4.0 [1.8–8.0] | 0.16 | 0.37 | 0.15 | 0.17 |