Fig. 5

Changes from baseline in PROs at week 24 by baseline biomarker tertile. LS mean differences in changes from baseline between sarilumab and adalimumab at week 24 by baseline biomarker tertile in a HAQ-DI and b pain VAS. *Nominal biomarker-by-treatment interaction vs. low tertile. Low, medium and high subgroups are based on biomarker tertile values in overall treatment groups (see Table S3 for tertile ranges). CI, confidence interval; CXCL13, chemokine (C-X-C motif) ligand 13; HAQ-DI, Health Assessment Questionnaire-Disability Index; LS, least squares; MMP-3, matrix metalloproteinase-3; NS, not significant at 5%; P1NP, procollagen type 1 N-terminal propeptide; SAA, serum amyloid A; VAS, visual analogue scale