Fig. 1

Cartilage-specific antibodies induced arthritis in BQ.Cia9i mice. Nine to 12-week-old BQ.Cia9i mice were injected with 2 or 4 mg of antibody cocktails. a Monoclonal antibody binding to cartilage in vivo. b Locally deposited C3 immune complexes are developed on the surface of cartilage within 48 h. c, d Infiltrating cells, joint surface erosions, and bone destructions on days 5 (c) and 21 (d) are shown (original mag. × 10). e Mean arthritis score (The results are based on combined data from 2 experiments with 5 mice per group. The individual experiment data are shown in Additional file 4: Fig. S1 a and b) and f histological scoring of inflammation using a scale of 0–3. g Representative pictures of sick paws. 2 mg Cab3 vs 2 mg anti-CII: *p < 0.05; 4 mg Cab3 vs 4 mg anti-CII: ^p < 0.05. Values are the mean ± SEM (n = 10)