Fig. 3
From: Cartilage-binding antibodies initiate joint inflammation and promote chronic erosive arthritis
Bone destructions induced by cartilage-binding antibodies. a, b The representative micro-CT images of isotype control, Cab3, and anti-CII group in lpsCAIA and mCAIA. c For the lpsCAIA group, bone mineral density (p = 0.07), trabecular bone volume as percent of tissue volume (*p = 0.02), cortical thickness (p = 0.90), trabecular number (**p = 0.003), trabecular spacing (*p = 0.04), and trabecular thickness (p = 0.26) were analyzed between Cab3 and isotype control (Isotype). d For the mCAIA group, bone mineral density (*p = 0.02), trabecular bone volume as a percent of tissue volume (*p = 0.02), cortical thickness (p = 0.23), trabecular number (*p = 0.04), trabecular spacing (*p = 0.01), and trabecular thickness (p = 0.06) in the distal region of the tibia were analyzed. *p < 0.05; **p < 0.01. The data are shown as mean ± SD (n = 3)