Fig. 4
From: Cartilage-binding antibodies initiate joint inflammation and promote chronic erosive arthritis
Antibody levels in BQ.Ncf1*mice with lpsCAIA and mCAIA. Measurement of the injected antibodies on days 0, 9, 21, 65, and 95 in lpsCAIA and mCAIA with BQ.Ncf1*mice. a Antibodies in Cab3 (M2139, L10D9, and 15A11) cocktail-injected mice bind to J1 (CII_T_J1_R), D3 (CII_T_D3_R), and COMP (ChCOMP15_CIT) epitopes, respectively, in lpsCAIA (above) and mCAIA (below). b Antibodies in anti-CII antibody cocktail (M2139, UL1, CIIC1, and CIIC2)-injected mice bind to J1 (CII_T_J1_R), U1 (CII_T_U1 R-R 498), C1 (CII_T_C1_R-R), and D3 (CII_T_D3_R) epitopes, respectively, in lpsCAIA (above) and mCAIA (below). Results show significance on days 0 and 95. The data shown are mean ± SEM