Cartilage-binding antibodies initiate joint inflammation and promote chronic erosive arthritis

Table 1 Information about the monoclonal antibodies used in this study

Antibody	Epitope	Structure and amino acid sequence	Isotypes	Reference
CIIC1	CII (C1)	358–369: GARGLTGRPGDA	IgG2a	[17]
CIIC2	CII (D3)	687–698: RGAQGPPGATGF	IgG2b	[17]
UL1	CII (U1)	494–504: LVGPRGERGFP	IgG2b	[31]
M2139	CII (J1)	551–564: MPGERRGAAGIAGPK	IgG2b	[32]
L10D9	CXI (D3)		IgG2a	[28]
15A11	COMP	EGF-repeat 4: PSPCHEKADCILERDGSRS	IgG1	[25]
ACC1	CII (CitC1)	CII121-144, CII241-264, CII571-591, CII 916-939 (F4 epitope), CII931-954, C1 (C1-T-CIT365), F4 (F4-T-CIT933), CII571-591	IgG2a	[23]
L243		Anti-HLA DR antibody	IgG2a	ATCC® HB-55™
G11		Anti-human parathyroid cells antibody	IgG2b	[33]
Hy2.15		Anti-hapten antibody	IgG1	[34]

All epitopes are in native triple helical form; amino acids are abbreviated as follows: G glycine, P proline or hydroxyproline, E glutamic acid, R arginine, K lysine, H histidine, F phenylalanine, A alanine, L leucine, T threonine, Y tyrosine

ISSN: 1478-6362