Skip to main content

Table 1 Information about the monoclonal antibodies used in this study

From: Cartilage-binding antibodies initiate joint inflammation and promote chronic erosive arthritis

Antibody Epitope Structure and amino acid sequence Isotypes Reference
CIIC1 CII (C1) 358–369: GARGLTGRPGDA IgG2a [17]
CIIC2 CII (D3) 687–698: RGAQGPPGATGF IgG2b [17]
UL1 CII (U1) 494–504: LVGPRGERGFP IgG2b [31]
M2139 CII (J1) 551–564: MPGERRGAAGIAGPK IgG2b [32]
L10D9 CXI (D3)   IgG2a [28]
15A11 COMP EGF-repeat 4: PSPCHEKADCILERDGSRS IgG1 [25]
ACC1 CII (CitC1) CII121-144, CII241-264, CII571-591, CII 916-939 (F4 epitope), CII931-954, C1 (C1-T-CIT365), F4 (F4-T-CIT933), CII571-591 IgG2a [23]
L243   Anti-HLA DR antibody IgG2a ATCC® HB-55™
G11   Anti-human parathyroid cells antibody IgG2b [33]
Hy2.15   Anti-hapten antibody IgG1 [34]
  1. All epitopes are in native triple helical form; amino acids are abbreviated as follows: G glycine, P proline or hydroxyproline, E glutamic acid, R arginine, K lysine, H histidine, F phenylalanine, A alanine, L leucine, T threonine, Y tyrosine