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Table 2 Disease incidence and maximum arthritis score in BQ.Cia9i mice

From: Cartilage-binding antibodies initiate joint inflammation and promote chronic erosive arthritis

Cocktail

B-LPS

A-LPS

Incidence

Max arthritis score (mean ± SEM)

Incidence

Max arthritis score (mean ± SEM)

2 mg Cab3

6/10

8.30 ± 2.82*

10/10

31.50 ± 3.22*

2 mg anti-CII

1/10

0.70 ± 0.70*

10/10

20.00 ± 3.16*

4 mg Cab3

8/10

10.40 ± 2.33^^

9/10

36.00 ± 2.80^

4 mg anti-CII

2/10

1.30 ± 1.01^^

10/10

27.90 ± 2.61^

  1. Comparisons were done between 2 mg/4 mg Cab3 and 2 mg/4 mg anti-CII in regard to max arthritis score. Significant difference was observed between two groups. Cab3: M2139 + L10D9 + 15A11; anti-CII: M2139 + UL1 + CIIC1 + CIIC2. B-LPS before lipopolysaccharide injection, A-LPS after lipopolysaccharide injection. 2 mg Cab3 vs 2 mg anti-CII: *p < 0.05; 4 mg Cab3 vs 4 mg anti-CII: ^p < 0.05, ^^p < 0.01. The two-tailed Mann-Whitney U test was used to calculate the level of significance
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Arthritis Research & Therapy

ISSN: 1478-6362

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