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Table 2 Disease incidence and maximum arthritis score in BQ.Cia9i mice

From: Cartilage-binding antibodies initiate joint inflammation and promote chronic erosive arthritis

Cocktail B-LPS A-LPS
Incidence Max arthritis score (mean ± SEM) Incidence Max arthritis score (mean ± SEM)
2 mg Cab3 6/10 8.30 ± 2.82* 10/10 31.50 ± 3.22*
2 mg anti-CII 1/10 0.70 ± 0.70* 10/10 20.00 ± 3.16*
4 mg Cab3 8/10 10.40 ± 2.33^^ 9/10 36.00 ± 2.80^
4 mg anti-CII 2/10 1.30 ± 1.01^^ 10/10 27.90 ± 2.61^
  1. Comparisons were done between 2 mg/4 mg Cab3 and 2 mg/4 mg anti-CII in regard to max arthritis score. Significant difference was observed between two groups. Cab3: M2139 + L10D9 + 15A11; anti-CII: M2139 + UL1 + CIIC1 + CIIC2. B-LPS before lipopolysaccharide injection, A-LPS after lipopolysaccharide injection. 2 mg Cab3 vs 2 mg anti-CII: *p < 0.05; 4 mg Cab3 vs 4 mg anti-CII: ^p < 0.05, ^^p < 0.01. The two-tailed Mann-Whitney U test was used to calculate the level of significance