Cartilage-binding antibodies initiate joint inflammation and promote chronic erosive arthritis

Table 4 Disease incidence and maximum arthritis score with common mouse strains

Cocktail	Mice	B-LPS		A-LPS
Cocktail	Mice	Incidence	Max arthritis score (mean ± SEM)	Incidence	Max arthritis score (mean ± SEM)
2 mg Cab3	DBA/1	4/7	2.00 ± 0.95	7/7	22.86 ± 3.48
	C57BL/6NQ	5/5	6.20 ± 1.50	5/5	28.40 ± 4.23*
	BALB/c	1/7	1.43 ± 1.43	6/7	12.71 ± 4.98*
4 mg Cab3	BALB/c	2/7	1.29 ± 1.13	6/7	20.29 ± 6.26

Comparisons were done in DBA/1, C57BL/6NQ, and Balb/c mice strains injected with 2 mg Cab3 in regard to max arthritis score. Significant difference was observed between C57BL/6NQ and Balb/c mice with 2 mg Cab3 after LPS injection. 2 mg Cab4 vs 2 mg anti-CII: *p < 0.05. The one-way ANOVA with Dunn’s multiple comparisons test was used to calculate the level of significance

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