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Table 2 Genotype-stratified analysis of the TNFAIP3-UBE2L3 interaction in SLE risk

From: Synergistic activation of NF-κB by TNFAIP3 (A20) reduction and UBE2L3 (UBCH7) augment that synergistically elevate lupus risk

Subgroup

N/nn

N/nr

N/rr

R/nn

R/nr

R/rr

Genotypea

TT/GG

TT/TG

TT/TT

(TG+GG)/GG

(TG+GG)/TG

(TG+GG)/TT

Controls

509

999

481

63

117

38

Cases

232

540

297

42

129

78

Pb

0.13

0.0090

0.21

1.6 × 10−7

8.4 × 10−11

ORb

1.0

1.2

1.3

1.3

2.3

4.1

ORint

1.5

2.4

  1. SLE systemic lupus erythematosus, OR odds ratio, CI confidence interval
  2. aIn the genotypes of TNFAIP3 rs2230926/UBE2L3 rs131654, shown in bold are their risk-associated alleles, which are more frequent in patient cases than healthy controls
  3. bUsing logistic regression with adjustment for age and gender of the participants