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Table 1 Performance of the modified 2010 criteria (incorporating the concordance serological score proposed by Regueiro et al.) compared to the original ACR/EULAR 2010 criteria for RA, with RA according to the 1987 criteria at 1 year as the gold standard

From: Substitution of the quantitative serological component in the 2010 criteria for RA with qualitative presence of three autoantibodies yields similar performance: response to the article by Regueiro et al.

Serological component

Sensitivity, % (95%CI)

Specificity, % (95%CI)

PPV, % (95%CI)

NPV, % (95%CI)

OR (95%CI)

2010 ACR/EULAR (quantitative)

84.5 (82.4–86.7)

68.8 (65.9–71.7)

74.9 (72.4–77.4)

80.2 (77.4–82.9)

12.1 (9.7–15.0)

Modified (qualitative)

82.3 (80.0–84.7)

71.6 (68.8–74.5)

76.2 (73.7–78.7)

78.7 (75.9–81.4)

11.8 (9.5–14.6)

  1. PPV positive predictive value, NPV negative predictive value, OR odds ratio, CI confidence interval