Fig. 3

Type III IFNs increase IFN-α production by pDCs stimulated with RNA-IC. The levels of IFN-α in supernatants from healthy donor pDCs stimulated with RNA-IC for 20 h in the presence of a IFN-λ1, b IFN-λ2, or c IFN-λ3 at indicated concentrations. No IFN production was detected in the absence of RNA-IC. Graphs show means with SEM based on six donors in two independent experiments. Friedman’s test. *p < 0.05, **p < 0.01, ***p < 0.001