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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: Presence of autoantibodies in “seronegative” rheumatoid arthritis associates with classical risk factors and high disease activity

Fig. 1

Co-occurrence of ACPA fine-specificities. a, b Correlation plots illustrating co-occurrence of different ACPA fine-specificities, in anti-CCP2-positive and anti-CCP2-negative RA. Correlation (Pearson r2) between binary antibody expression vectors, among patients that were positive for at least one ACPA fine-specificity, are shown; plotted using corrplot (v.0.77). The degree of correlation is illustrated in colours, according to Pearson’s correlation coefficient (scale shown on the right). c, d The number of ACPA fine-specificities in anti-CCP2-negative RA and controls. The frequency (%) of anti-CCP2-negative RA patients and controls with 1, 2–3, 4–10, or > 10 ACPA fine-specificities, and the number of ACPA per individual patient/control, are shown. Only ACPA-positive individuals with higher reactivity against citrulline compared to arginine-containing peptides were included in the analysis

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