|
Subgroup
|
Exposure
| |
|---|
| |
SE−
|
SE+
|
OR (95% CI)a
|
OR (95% CI)b
|
|
Controls
|
1341
|
1456
|
1.0 (ref)
|
1.0 (ref)
|
|
ACPA−
|
246
|
265
|
0.99 (0.82–1.2)
|
1.00 (0.83–1.21)
|
|
ACPA+
|
126
|
176
|
1.29 (1.01–1.64)
|
1.30 (1.02–1.65)
|
|
RF−
|
258
|
293
|
1.04 (0.87–1.26)
|
1.05 (0.88–1.27)
|
|
RF+
|
114
|
148
|
1.20 (0.93–1.55)
|
1.21 (0.94–1.57)
|
|
Other Ab−
|
242
|
316
|
1.20 (1.00–1.45)
|
1.22 (1.01–1.46)
|
|
Other Ab+
|
130
|
125
|
0.88 (0.68–1.14)
|
0.89 (0.69–1.15)
|
| |
Never smoker
|
Ever smoker
|
OR (95% CI)a
|
OR (95% CI)c
|
|
Controls
|
1208
|
1589
|
1.0 (ref)
|
1.0 (ref)
|
|
ACPA−
|
184
|
327
|
1.35 (1.11–1.64)
|
1.34 (1.10–1.63)
|
|
ACPA+
|
121
|
181
|
1.16 (0.91–1.48)
|
1.15 (0.90–1.47)
|
|
RF−
|
221
|
330
|
1.13 (0.94–1.36)
|
1.13 (0.93–1.36)
|
|
RF+
|
84
|
178
|
1.65 (1.26–2.16)
|
1.63 (1.24–2.14)
|
|
other Ab-
|
203
|
355
|
1.33 (1.10–1.60)
|
1.32 (1.09–1.59)
|
|
other Ab+
|
102
|
153
|
1.16 (0.89–1.51)
|
1.16 (0.89–1.51)
|
- Odds ratios were adjusted for aage, sex, and residential area, bPTPN22 and smoking, or cSE and PTPN22. ACPA = any ACPA fine-specificity; RF = IgM and/or IgG and/or IgA RF; other Ab = any other autoantibody
