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Table 2 Associations between autoantibodies and risk factors, in anti-CCP2− RA

From: Presence of autoantibodies in “seronegative” rheumatoid arthritis associates with classical risk factors and high disease activity

Subgroup Exposure  
  SE− SE+ OR (95% CI)a OR (95% CI)b
Controls 1341 1456 1.0 (ref) 1.0 (ref)
ACPA− 246 265 0.99 (0.82–1.2) 1.00 (0.83–1.21)
ACPA+ 126 176 1.29 (1.01–1.64) 1.30 (1.02–1.65)
RF− 258 293 1.04 (0.87–1.26) 1.05 (0.88–1.27)
RF+ 114 148 1.20 (0.93–1.55) 1.21 (0.94–1.57)
Other Ab− 242 316 1.20 (1.00–1.45) 1.22 (1.01–1.46)
Other Ab+ 130 125 0.88 (0.68–1.14) 0.89 (0.69–1.15)
  Never smoker Ever smoker OR (95% CI)a OR (95% CI)c
Controls 1208 1589 1.0 (ref) 1.0 (ref)
ACPA− 184 327 1.35 (1.11–1.64) 1.34 (1.10–1.63)
ACPA+ 121 181 1.16 (0.91–1.48) 1.15 (0.90–1.47)
RF− 221 330 1.13 (0.94–1.36) 1.13 (0.93–1.36)
RF+ 84 178 1.65 (1.26–2.16) 1.63 (1.24–2.14)
other Ab- 203 355 1.33 (1.10–1.60) 1.32 (1.09–1.59)
other Ab+ 102 153 1.16 (0.89–1.51) 1.16 (0.89–1.51)
  1. Odds ratios were adjusted for aage, sex, and residential area, bPTPN22 and smoking, or cSE and PTPN22. ACPA = any ACPA fine-specificity; RF = IgM and/or IgG and/or IgA RF; other Ab = any other autoantibody