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Table 4 Disease activity during 5-years follow-up, in relation to autoantibody status

From: Presence of autoantibodies in “seronegative” rheumatoid arthritis associates with classical risk factors and high disease activity

RA subseta   0 m 3 m 6 m 12 m 24 m 36 m 48 m 60 m
Seronegative DAS28 5.10 3.49 3.25 2.72 2.33 2.14 1.96 2.2.11
n 163 138 139 154 148 73 47 103
Ab+ DAS28 5.37 3.59 3.34 2.80 2.68 2.63 2.97 2.02
n 123 110 107 119 104 56 35 62
ACPA+ DAS28 5.34 3.63 3.41 2.94 2.71 2.99 3.66 2.20
n 87 77 79 84 75 40 21 41
RF+ DAS28 5.50 3.67 3.49 2.49 2.27 2.61 3.17 1.88
n 27 23 23 26 24 13 8 12
Carb+ DAS18 5.50 3.30 3.35 2.77 2.66 2.13 2.20 1.78
n 43 38 33 40 33 16 14 24
ACPA+/Carb− DAS28 5.15 3.66 3.44 3.01 2.76 3.23 3.69 2.37
n 68 61 64 67 60 33 16 32
ACPA−/Carb+ DAS28 5.57 3.14 3.30 2.75 2.74 1.89 1.91 1.71
n 24 22 18 23 18 9 9 15
Seropositive DAS28 5.08 3.67 3.25 3.02 2.71 2.94 2.87 2.75
n 747 650 595 719 685 444 315 522
  1. aAll RA subsets (with the exception of seropositive RA) are anti-CCP2 IgG−/IgM RF−; Ab+ = ACPA+, and/or IgA RF+, and/or IgG RF+, and/or anti-CarP+; seropositive = anti-CCP2 IgG+ and/or IgM RF+. Median DAS28-CRP values are shown for each RA subset (significantly higher DAS28-CRP compared to seronegative RA in bold). N = number of patients in each subset at each time point. 0 m = baseline; 3–60 m = 3 months to 60 months follow-up period