Fig. 2
From: Increased serum calpain activity is associated with HMGB1 levels in systemic sclerosis
Increased serum calpain activity and HMGB1 levels in SSc patients. a Significantly higher serum calpain activity and HMGB1 levels (d) were found in SSc patients than in HC and in patients with other CTD. b Patients with dSSc showed significantly higher serum calpain activity and HMGB1 levels (e) than patients with lSSc. c SSc patients with ILD showed significantly higher serum calpain activity and HMGB1 levels (f) than SSc patients without ILD. g Correlations between serum calpain activity and HMGB1 levels from patients with SSc. The short bar indicates mean ± 2SD in each group. ***< 0.001, **< 0.01, *< 0.05. Abbreviations: SSc systemic sclerosis, ILD interstitial lung disease, CTD connective tissue diseases, HC healthy control subjects, SD standard deviation, dSSc diffuse cutaneous systemic sclerosis, lSSc limited cutaneous systemic sclerosis