Increased serum calpain activity is associated with HMGB1 levels in systemic sclerosis

Zheng, Ji-Na; Li, Yang; Yan, Yue-Mei; Yu, Yong; Shao, Wen-Qi; Wang, Qiang

doi:10.1186/s13075-020-02195-y

Arthritis Research & Therapy

Table 2 Clinical and laboratory characteristics of SSc patients according to serum calpain activity and HMGB1 levels

From: Increased serum calpain activity is associated with HMGB1 levels in systemic sclerosis

Characteristics	Calpain^high, n = 10	Calpain^low, n = 21	p value	HMGB-1^high, n = 12	HMGB-1^low, n = 19	p value
Age (mean ± SD)	48 ± 13	53 ± 13	0.311	49 ± 14	53 ± 12	0.358
Female,n(%)	8 (80)	19 (90)	0.577	11 (92)	16 (84)	0.958
Course of disease (mean ± SD)	10 ± 11	7 ± 6	0.299	7 ± 2	8 ± 2	0.946
dSSc/lSSc	5/5	12/9	0.709	8 (67)	6 (32)	0.075
PAH,n(%)	2 (20)	3 (14)	0.690	4 (33)	1 (5)	0.060
SSc-ILD,n(%)	8 (80)	16 (76)	0.813	11 (92)	13 (68)	0.201
Raynaud’s phenomenon,n(%)	9 (90)	18 (86)	0.734	11 (92)	16 (84)	0.958
Anti-Scl-70 antibody,n(%)	1 (10)	12 (57)	0.020*	5 (42)	8 (42)	0.981
ANA,n(%)	10 (100)	20 (95)	0.483	12 (100)	18 (95)	0.999
Anti-RNP,n(%)	4 (40)	4 (19)	0.381	4 (33)	4 (21)	0.676
Anti-centromere,n(%)	3 (30)	5 (24)	0.715	5 (42)	3 (16)	0.206
mRSS (mean ± SD)n = 26	19 ± 13	9 ± 6	0.012*	9 ± 5	15 ± 12	0.098
FVC % predicted,n = 17 (mean ± SD)	64.85 ± 35.29	54.27 ± 35.40	0.545	52.63 ± 33.50	63.80 ± 36.46	0.472
DL_CO% predicted,n = 8 (mean ± SD)	81.74 ± 32.99	66.57 ± 11.25	0.488	61.35 ± 20.29	80.79 ± 27.21	0.387
FEV1/FVC%n = 17 (mean ± SD)	88.42 ± 15.84	85.53 ± 8.49	0.638	83.58 ± 9.22	88.97 ± 12.79	0.344
ESR, mm/h (mean ± SD)	11.10 ± 5.04	19.95 ± 11.77	0.031*	13.92 ± 8.45	19.11 ± 11.90	0.167
Platelets count, 10⁹/L (mean ± SD)	201 ± 71	209 ± 66	0.772	194 ± 83	214 ± 56	0.442
MPV, fL (mean ± SD)	11.59 ± 1.66	10.64 ± 1.33	0.096	11.25 ± 1.82	10.75 ± 1.25	0.373
PDW, fL (mean ± SD)	0.22 ± 0.07	0.22 ± 0.07	0.867	0.21 ± 0.08	0.23 ± 0.06	0.480
PCT, % (mean ± SD)	37.74 ± 11.69	28.04 ± 9.62	0.021*	30.98 ± 12.95	31.29 ± 10.20	0.944
P-LCR, % (mean ± SD)	15.17 ± 3.94	12.66 ± 2.68	0.045*	14.08 ± 4.01	13.08 ± 2.81	0.465

Abbreviations: SSc systemic sclerosis, ILD interstitial lung disease, PAH pulmonary arterial hypertension, HC healthy control subjects, SD standard deviation, dcSSc diffuse cutaneous systemic sclerosis, lcSSc limited cutaneous systemic sclerosis, ANA antinuclear antibodies, anti-RNP anti-ribonucleoprotein antibody, mRSS modified Rodnan skin score, FVC forced vital capacity, DL_CO diffusing capacity of the lung for carbon monoxide, FEV1 forced the first second of expiratory volume, ESR erythrocyte sedimentation rate, PLT platelet count, PDW platelet distribution width, PCT plateletcrit, MPV mean platelet volume, P-LCR platelet large cell ratio, ANCA anti-neutrophil cytoplasmic antibodies, NA not available. *p < 0.05

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