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Table 2 Clinical and laboratory characteristics of SSc patients according to serum calpain activity and HMGB1 levels

From: Increased serum calpain activity is associated with HMGB1 levels in systemic sclerosis

CharacteristicsCalpainhigh, n = 10Calpainlow, n = 21p valueHMGB-1high, n = 12HMGB-1low, n = 19p value
Age (mean ± SD)48 ± 1353 ± 130.31149 ± 1453 ± 120.358
Female,n(%)8 (80)19 (90)0.57711 (92)16 (84)0.958
Course of disease (mean ± SD)10 ± 11± 60.299± 2± 20.946
dSSc/lSSc5/512/90.7098 (67)6 (32)0.075
PAH,n(%)2 (20)3 (14)0.6904 (33)1 (5)0.060
SSc-ILD,n(%)8 (80)16 (76)0.81311 (92)13 (68)0.201
Raynaud’s phenomenon,n(%)9 (90)18 (86)0.73411 (92)16 (84)0.958
Anti-Scl-70 antibody,n(%)1 (10)12 (57)0.020*5 (42)8 (42)0.981
ANA,n(%)10 (100)20 (95)0.48312 (100)18 (95)0.999
Anti-RNP,n(%)4 (40)4 (19)0.3814 (33)4 (21)0.676
Anti-centromere,n(%)3 (30)5 (24)0.7155 (42)3 (16)0.206
mRSS (mean ± SD)n = 2619 ± 13± 60.012*± 515 ± 120.098
FVC % predicted,n = 17 (mean ± SD)64.85 ± 35.2954.27 ± 35.400.54552.63 ± 33.5063.80 ± 36.460.472
DLCO% predicted,n = 8 (mean ± SD)81.74 ± 32.9966.57 ± 11.250.48861.35 ± 20.2980.79 ± 27.210.387
FEV1/FVC%n = 17 (mean ± SD)88.42 ± 15.8485.53 ± 8.490.63883.58 ± 9.2288.97 ± 12.790.344
ESR, mm/h (mean ± SD)11.10 ± 5.0419.95 ± 11.770.031*13.92 ± 8.4519.11 ± 11.900.167
Platelets count, 109/L (mean ± SD)201 ± 71209 ± 660.772194 ± 83214 ± 560.442
MPV, fL (mean ± SD)11.59 ± 1.6610.64 ± 1.330.09611.25 ± 1.8210.75 ± 1.250.373
PDW, fL (mean ± SD)0.22 ± 0.070.22 ± 0.070.8670.21 ± 0.080.23 ± 0.060.480
PCT, % (mean ± SD)37.74 ± 11.6928.04 ± 9.620.021*30.98 ± 12.9531.29 ± 10.200.944
P-LCR, % (mean ± SD)15.17 ± 3.9412.66 ± 2.680.045*14.08 ± 4.0113.08 ± 2.810.465
  1. Abbreviations: SSc systemic sclerosis, ILD interstitial lung disease, PAH pulmonary arterial hypertension, HC healthy control subjects, SD standard deviation, dcSSc diffuse cutaneous systemic sclerosis, lcSSc limited cutaneous systemic sclerosis, ANA antinuclear antibodies, anti-RNP anti-ribonucleoprotein antibody, mRSS modified Rodnan skin score, FVC forced vital capacity, DLCO diffusing capacity of the lung for carbon monoxide, FEV1 forced the first second of expiratory volume, ESR erythrocyte sedimentation rate, PLT platelet count, PDW platelet distribution width, PCT plateletcrit, MPV mean platelet volume, P-LCR platelet large cell ratio, ANCA anti-neutrophil cytoplasmic antibodies, NA not available. *p < 0.05