Increased serum calpain activity is associated with HMGB1 levels in systemic sclerosis

Table 3 Univariate and multivariate logistic regression of clinical and laboratory parameters to ILD in patients with SSc

Hub genes/clinical traits	Univariate logistic regression			Multivariate logistic regression
Hub genes/clinical traits	OR	95% CI	p value	OR	95% CI	p value
Gender	1.578	0.218, 7.618	0.929
Age	0.943	0.878, 1.013	0.108
Course of disease	0.991	0.898, 1.093	0.857
Raynaud’s phenomenon	0.421	0.050, 3.532	0.425
Anti-Scl-70 antibody (+)	2.121	0.428, 10.515	0.357
ANA (+)	0.970	0.982, 1.0010	0.834
Anti-RNP (+)	0.353	0.066, 1.874	0.221
Anti-centromere (+)	4.500	0.471, 42.970	0.191
mRSS	0.876	0.770, 0.997	0.044*	0.917	0.807, 1.042	0.184
FVC (%predict)	1.003	0.973, 1.033	0.865
DL_CO (%predict)	1.071	0.934, 1.228	0.325
FEV1/FVC%	1.087	0.944, 1.253	0.245
ESR, mm/h	0.991	0.925, 1.062	0.800
PLT, 10⁹/L	0.999	0.987, 1.010	0.850
MPV, fL	0.829	0.503, 1.365	0.461
PDW, fL	0.282	0.000, 21.236	0.825
PCT, %	0.959	0.895, 1.028	0.235
P-LCR, %	0.916	0.730, 1.149	0.449
Calpain activity	1.057	1.002, 1.115	0.041*	1.063	0.968, 1.166	0.202
HMGB1	1.190	1.006, 1.408	0.043*	1.414	0.953, 2.096	0.085

Abbreviations: CI confidence interval, OR odds ratio, SSc systemic sclerosis, ILD interstitial lung disease, ANA antinuclear antibodies, anti-RNP anti-ribonucleoprotein antibody, mRSS modified Rodnan skin score, FVC forced vital capacity, DL_CO diffusing capacity of the lung for carbon monoxide, FEV1 forced the first second of expiratory volume, ESR erythrocyte sedimentation rate, PLT platelet count, PDW platelet distribution width, PCT plateletcrit, MPV mean platelet volume, P-LCR platelet large cell ratio, RA rheumatoid arthritis, ANCA anti-neutrophil cytoplasmic antibodies, NA not available
*p < 0.05

ISSN: 1478-6362