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Table 3 Univariate and multivariate logistic regression of clinical and laboratory parameters to ILD in patients with SSc

From: Increased serum calpain activity is associated with HMGB1 levels in systemic sclerosis

Hub genes/clinical traitsUnivariate logistic regressionMultivariate logistic regression
OR95% CIp valueOR95% CIp value
Gender1.5780.218, 7.6180.929   
Age0.9430.878, 1.0130.108   
Course of disease0.9910.898, 1.0930.857   
Raynaud’s phenomenon0.4210.050, 3.5320.425   
Anti-Scl-70 antibody (+)2.1210.428, 10.5150.357   
ANA (+)0.9700.982, 1.00100.834   
Anti-RNP (+)0.3530.066, 1.8740.221   
Anti-centromere (+)4.5000.471, 42.9700.191   
mRSS0.8760.770, 0.9970.044*0.9170.807, 1.0420.184
FVC (%predict)1.0030.973, 1.0330.865   
DLCO (%predict)1.0710.934, 1.2280.325   
FEV1/FVC%1.0870.944, 1.2530.245   
ESR, mm/h0.9910.925, 1.0620.800   
PLT, 109/L0.9990.987, 1.0100.850   
MPV, fL0.8290.503, 1.3650.461   
PDW, fL0.2820.000, 21.2360.825   
PCT, %0.9590.895, 1.0280.235   
P-LCR, %0.9160.730, 1.1490.449   
Calpain activity1.0571.002, 1.1150.041*1.0630.968, 1.1660.202
HMGB11.1901.006, 1.4080.043*1.4140.953, 2.0960.085
  1. Abbreviations: CI confidence interval, OR odds ratio, SSc systemic sclerosis, ILD interstitial lung disease, ANA antinuclear antibodies, anti-RNP anti-ribonucleoprotein antibody, mRSS modified Rodnan skin score, FVC forced vital capacity, DLCO diffusing capacity of the lung for carbon monoxide, FEV1 forced the first second of expiratory volume, ESR erythrocyte sedimentation rate, PLT platelet count, PDW platelet distribution width, PCT plateletcrit, MPV mean platelet volume, P-LCR platelet large cell ratio, RA rheumatoid arthritis, ANCA anti-neutrophil cytoplasmic antibodies, NA not available
  2. *p < 0.05