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Table 2 Onset symptoms and organs involvement of IgG4-RD patients with/without PAO/PA

From: IgG4-related aortitis/periaortitis and periarteritis: a distinct spectrum of IgG4-related disease

Symptoms and organs affected at baseline

PAO/PA

Non-PAO/PA

P value

Symptoms at disease onset (n, %)

 Back pain

32 (36)

21 (4.2)

< 0.001*

 Lymph node swelling

22 (24.7)

137 (27.5)

0.575

 Abdominal pain

25 (28.1)

79 (15.9)

0.005*

 Submandibular gland enlargement

18 (20.2)

213 (42.8)

< 0.001*

 Lacrimal gland enlargement

10 (11.2)

227 (45.6)

< 0.001*

 Lower limb edema

14 (15.7)

8 (1.6)

< 0.001*

 Cough

11 (12.4)

53 (10.6)

0.632

 Nausea and vomiting

12 (11.1)

42 (8.4)

0.129

 Jaundice

8 (9.0)

72 (14.5)

0.166

 Parotid gland enlargement

5 (5.6)

66 (13.3)

0.042*

 Nasal congestion

4 (4.5)

106 (21.3)

< 0.001*

 Itching

5 (5.6)

45 (9.0)

0.287

Organs affected (n, %)

 Lymph node

33 (37.1)

219 (44)

0.674

 Submandibular gland

24 (27.0)

259 (52)

< 0.001*

 Pancreas

26 (29.2)

175 (35.5)

0.278

 Lung

15 (16.9)

117 (23.5)

0.167

 Lacrimal gland

11 (12.4)

266 (53.4)

< 0.001*

 Parotid gland

9 (10.1)

90 (18.1)

0.065

 Bile duct

11 (12.4)

99 (19.9)

0.094

 Paranasal sinus

8 (9.0)

155 (31.1)

< 0.001*

 Prostate

12 (15.8)

39 (13.6)

0.632

 Kidney

6 (6.7)

44 (8.8)

0.515

 Thyroid

2 (2.2)

21 (4.2)

0.378

 Pituitary

2 (2.2)

9 (1.8)

0.778

 Skin

1 (1.1)

28 (5.6)

0.071