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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Circulating TNF-like protein 1A (TL1A) is elevated early in rheumatoid arthritis and depends on TNF

Fig. 2

TL1A elevation in rheumatoid arthritis and other diseases. a Soluble TL1A was measured in SF from patients diagnosed with RA (n = 39) or other types of arthritis (non-RA, n = 37) including psoriatic arthritis, crystal-induced arthritis, reactive arthritis, non-inflammatory arthritis, nonspecific inflammatory arthritis, JIA, or infectious arthritis. Values are shown with a line representing the median value and significance of the difference between RA and non-RA samples p ≤ 0.0001 (Mann-Whitney test). b TL1A was measured in matching blood plasma samples as in a. p = 0.0002 (Mann-Whitney test). c TL1A levels in matched synovial fluid and plasma samples from RA patients (n = 39) were compared. Non-parametric correlation of SF vs. plasma TL1A is shown with the indicated Spearman’s ρ and p value. d Soluble TL1A was measured in synovial fluid (SF) from patients diagnosed with RA (n = 34) and osteoarthritis (OA) (n = 27). Values are shown with a line representing the median value and significance of the difference between RA and OA samples. p = 0.143 (Mann-Whitney test). e TL1A was measured in serum samples from patients diagnosed with RA (n = 98) and OA (n = 30) ****p ≤ 0.0001 (Mann-Whitney test). f TL1A levels in matched synovial fluid and serum samples from RA patients (n = 34) were compared. One outlier with very high TL1A in both serum (5.6 ng/ml) and SF (8.4 ng/ml) was removed from the analysis. Non-parametric correlation of SF vs. serum TL1A is shown with the indicated Spearman’s ρ and p value. For all panels. g TL1A was measured in SF from patients diagnosed with the indicated diseases using a bead-based immunoassay as described in the methods. RA n = 17; OA, n = 21; gout/CPPD (calcium pyrophosphate disease), n = 10; PsA (psoriatic arthritis), n = 11. Asterisks represent significances compared to OA (Mann-Whitney test) *p ≤ 0.05, ***p ≤ 0.001. h TL1A and TNF levels in SF from RA patients were measured by a bead-based assay as described in the methods. i Serum TL1A was measured as in g from patients diagnosed with the indicated diseases: RA, n = 20; AS ankylosing spondylitis, n = 40; Sjögren’s syndrome, n = 59; SLE systemic lupus erythematosus, n = 20; control, n = 10. Asterisks represent p value compared to control group **p ≤ 0.01, ***p ≤ 0.001 (Mann-Whitney test). j TL1A was measured in the serum of patients with hepatitis C with the indicated status for circulating cryoglobulins and/or rheumatoid factor

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