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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: Circulating TNF-like protein 1A (TL1A) is elevated early in rheumatoid arthritis and depends on TNF

Fig. 5

Blocking TL1A-DR3 interactions prevents disease and bone erosions in collagen-induced arthritis. a CIA was induced in DBA/1 mice as described in the methods. Weekly intra-peritoneal injections of 20 mg/kg of either anti-TL1A (treatment, n = 5) or hamster immunoglobulin Ig control (n = 7) were begun at day 21 after initial immunization with collagen. A representative experiment of three independent experiments is shown. Clinical scores on each day were compared using an unpaired t test, and p values for significance are shown above each time-point represented by asterisks (*p < 0.05, **p < 0.01) above each day. Two-way ANOVA was also performed to compare the trend of the two graphs, with p value shown to the right. b Survival analysis of the percentage of mice without arthritis on each day is compared between the anti-TL1A treated group and control group. Arthritis was defined by a combined clinical score of two or more. c Sera from mice from each group induced to develop CIA as in a were collected at indicated time points and anti-chicken collagen IgG levels were measured by ELISA. d 3-D reconstructions of micro-CT examination of hind paws from mice induced to develop CIA with and without TL1A blockade. Examples are shown from each treatment group, with the maximal clinical scores and the erosion score obtained for that paw by two separate observers blinded to treatment groups. e Composite of CT erosion scores obtained from the anti-TL1A treated group (n = 18) and control-antibody treated group (n = 20), significance is from an unpaired t test with Welch’s correlation (*p ≤ 0.05). Analysis of individual regions resulted in p values of 0.078 at ankle/tarsus, 0.042 at metatarsophalangeal (MTP) joints, and 0.015 at toes. f Comparison of the CT scores of the paws from the two groups based on the maximum clinical scores. Anti-TL1A treatment significantly reduced erosions independent of the clinical score. p < 0.0001 by 2-way ANOVA

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