Interleukin-18 and fibroblast growth factor 2 in combination is a useful diagnostic biomarker to distinguish adult-onset Still’s disease from sepsis

Table 3 ROC curve in each subset determined by multiple logistic regression analysis

Variables (AOSD vs. sepsis)	Sensitivity	Specificity	Accuracy	AUC	AIC	Cutoff value (pg/mL)
IL-18	93.7	83.3	91.4	0.884	65.67	543
GM-CSF	85.3	83.3	84.9	0.88	61.33	4.4
FGF-2	82.4	88.9	83.7	0.864	62.5	36
VEGF	66.2	88.9	70.9	0.85	70.55	221
IL-18 > 543 pg/mL + FGF-2 > 36 pg/mL	100	72.2	93.8	0.966	29.7
IL-18 > 543 pg/mL + GM-CSF > 4.4 pg/mL	92.1	83.3	90.1	0.944	37.1
FGF-2 > 36 pg/mL + GM-CSF > 4.4 pg/mL	89.7	83.3	88.4	0.877	59.32

Data in boldface indicates the minimum number of cytokines among the subsets. AIC Akaike’s information criterion, AUC area under the curve, FGF-2 fibroblast growth factor 2, GM-CSF granulocyte macrophage colony-stimulating factor

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