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Table 1 Characteristics of SNPs for circulating SHBG concentration from GWAS meta-analysis

From: Sex hormone-binding globulin and arthritis: a Mendelian randomization study

Gene

SNP

Chromosome: position (hg19)

EA

Association with exposure

β (SE)

P value

PRMT6

rs17496332

1: 107546375

G

0.028 (0.0041)

1.40E−11

GCKR

rs780093

2: 27742603

C

0.032 (0.0039)

2.20E−16

BAIAP2L1

rs3779195

7: 97993362

T

0.028 (0.0051)

2.70E−08

ZBTB10

rs440837

8: 81461974

G

0.028 (0.0047)

3.40E−09

JMJD1C

rs7910927

10: 65138910

G

0.048 (0.0039)

6.10E−35

SLCO1B1

rs4149056

12: 21331549

T

0.029 (0.0052)

1.90E−08

NR2F2

rs8023580

15: 96708291

C

0.030 (0.0044)

8.30E−12

ZNF652

rs2411984

17: 47445751

A

0.033 (0.0044)

3.50E−14

SHBG

rs12150660

17: 7521915

T

0.103 (0.0047)

1.80E−106

SHBG

rs6258

17: 7534678

T

− 0.272 (0.017)

1.03E−60

SHBG

rs1641537

17: 7545721

C

0.081 (0.0062)

8.19E−39

TP53

rs1625895

17: 7578115

C

0.052 (0.0067)

1.17E−14

TDGF3

rs1573036

X: 109820068

T

0.028 (0.0037)

4.10E−14

  1. Gene nearest gene to SHBG associated SNP, EA effect allele, β per allele effect on SHBG levels, SE standard error, P value P value for the genetic association