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Table 5 Mean, standard deviation (SD), and range of HCQ (ng/mL) measured in the three matrices. Three dose levels were prescribed (1400, 2000, and 2800 mg/week) and four patients (A–D) were sampled twice

From: Measurement of hydroxychloroquine in blood from SLE patients using LC-HRMS—evaluation of whole blood, plasma, and serum as sample matrices

 

HCQ Conc ng/mL

Whole blood

Serum

Plasma

Mean and range. All doses (n = 25a)

813 ± 466 (n.d.b–1989)

436 ± 270 (n.d.b–1194)

362 ± 224 (n.d.b − 1158)

Mean and range. Dose 1400 mg/week (n = 14)

697 ± 395 (n.d.–1606)

416 ± 209 (n.d.–868)

390 ± 271 (n.d.–1158)

Mean and range. Dose 2000 mg/week (n = 9)

832 ± 461 (98–1522)

406 ± 281 (41–1018)

287 ± 152 (23–611)

Mean and range. Dose 2800 mg/week (n = 2)

1282 ± 651 (709–1989)

641 ± 480 (350–1194)

505 ± 133 (404–656)

Patient A, 1st and 2nd sample, 10 days between samplings (2000 mg/week)

503, 216

235, 100

286, 124

Patient B, 1st and 2nd sample, 10 days between samplings (2000 mg/week)

680, 717

242, 363

223, 288

Patient C, 1st and 2nd sample, 60 days between samplings (1400 mg/week)

390, 298

292, 371

350, 235

Patient D, 1st and 2nd sample, 60 days between samplings (2800 mg/week)

709, 1147

350, 378

456, 404

  1. aThe patient with no HCQ administered (0 mg/week) is excluded from this table
  2. bn.d. not detected; excluded from the calculation of mean and SD