HCQ Conc ng/mL | |||
---|---|---|---|
Whole blood | Serum | Plasma | |
Mean and range. All doses (n = 25a) | 813 ± 466 (n.d.b–1989) | 436 ± 270 (n.d.b–1194) | 362 ± 224 (n.d.b − 1158) |
Mean and range. Dose 1400 mg/week (n = 14) | 697 ± 395 (n.d.–1606) | 416 ± 209 (n.d.–868) | 390 ± 271 (n.d.–1158) |
Mean and range. Dose 2000 mg/week (n = 9) | 832 ± 461 (98–1522) | 406 ± 281 (41–1018) | 287 ± 152 (23–611) |
Mean and range. Dose 2800 mg/week (n = 2) | 1282 ± 651 (709–1989) | 641 ± 480 (350–1194) | 505 ± 133 (404–656) |
Patient A, 1st and 2nd sample, 10 days between samplings (2000 mg/week) | 503, 216 | 235, 100 | 286, 124 |
Patient B, 1st and 2nd sample, 10 days between samplings (2000 mg/week) | 680, 717 | 242, 363 | 223, 288 |
Patient C, 1st and 2nd sample, 60 days between samplings (1400 mg/week) | 390, 298 | 292, 371 | 350, 235 |
Patient D, 1st and 2nd sample, 60 days between samplings (2800 mg/week) | 709, 1147 | 350, 378 | 456, 404 |