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Table 5 Mean, standard deviation (SD), and range of HCQ (ng/mL) measured in the three matrices. Three dose levels were prescribed (1400, 2000, and 2800 mg/week) and four patients (A–D) were sampled twice

From: Measurement of hydroxychloroquine in blood from SLE patients using LC-HRMS—evaluation of whole blood, plasma, and serum as sample matrices

 HCQ Conc ng/mL
Whole bloodSerumPlasma
Mean and range. All doses (n = 25a)813 ± 466 (n.d.b–1989)436 ± 270 (n.d.b–1194)362 ± 224 (n.d.b − 1158)
Mean and range. Dose 1400 mg/week (n = 14)697 ± 395 (n.d.–1606)416 ± 209 (n.d.–868)390 ± 271 (n.d.–1158)
Mean and range. Dose 2000 mg/week (n = 9)832 ± 461 (98–1522)406 ± 281 (41–1018)287 ± 152 (23–611)
Mean and range. Dose 2800 mg/week (n = 2)1282 ± 651 (709–1989)641 ± 480 (350–1194)505 ± 133 (404–656)
Patient A, 1st and 2nd sample, 10 days between samplings (2000 mg/week)503, 216235, 100286, 124
Patient B, 1st and 2nd sample, 10 days between samplings (2000 mg/week)680, 717242, 363223, 288
Patient C, 1st and 2nd sample, 60 days between samplings (1400 mg/week)390, 298292, 371350, 235
Patient D, 1st and 2nd sample, 60 days between samplings (2800 mg/week)709, 1147350, 378456, 404
  1. aThe patient with no HCQ administered (0 mg/week) is excluded from this table
  2. bn.d. not detected; excluded from the calculation of mean and SD