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Table 6 Reproducibility testing. To evaluate the reproducibility of the protocol used, eight patient samples were extracted and analyzed at two separate occasions for all three matrices. Five QC samples (QCL and QCH) were prepared on both occasions. The reproducibility of the QC samples was high in all matrices and in patients’ samples measuring WB

From: Measurement of hydroxychloroquine in blood from SLE patients using LC-HRMS—evaluation of whole blood, plasma, and serum as sample matrices

 Whole bloodSerumPlasma
Mean (ng/mL)a915455384
SD (ng/mL)b2765148
CV (%)c31439
QCL (25 ng/mL), CV%445
QCH (4556.3 ng/mL), CV%344
  1. aMean of all measurements, eight samples measured twice
  2. bMean of the SD from comparing two measurements of the same sample, reflects reproducibility
  3. cMean of the CV from comparing two measurements of the same sample, reflects reproducibility