Table 7 Evaluation of alternative protocols for HCQ levels in serum. Seven patient serum samples were prepared with the present method as well as the two alternative methods on two occasions. All methods showed high reproducibility for the measurement of HCQ in QC samples, but no method showed improved reproducibility for patient samples
Method | Alt. Method 1a CV% | Alt. Method 2b CV% | Current method CV% |
|---|---|---|---|
Samples (n = 7) | 16 | 17 | 15 |
QCL (n = 5) | 2 | 3 | 4 |
QCH (n = 5) | 3 | 4 | 4 |