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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: IL-23 in arthritic and inflammatory pain development in mice

Fig. 4

IL-23 is required for CCL17-driven arthritic pain and disease development. mBSA/CCL17 arthritis (mBSA i.a. [day 0]; CCL17 or saline s.c. [day 0–2]) was induced in WT and Il23p19−/− mice. Pain (incapacitance meter) and arthritis (histology, day 7) were measured. Data are expressed as mean ± SEM; WT female mice (mBSA/saline, n = 8; mBSA/CCL17, n = 8), Il23p19−/− female mice (mBSA/saline, n = 8; mBSA/CCL17, n = 9). For statistical analysis, a two-way ANOVA was used. ##P < 0.01, ###P < 0.001, WT saline vs. WT CCL17. ***P < 0.001, WT CCL17 vs. Il23p19−/− CCL17

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