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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: IL-23 in arthritic and inflammatory pain development in mice

Fig. 5

IL-23 is required for GM-CSF-, TNF-, and CCL17-driven inflammatory pain. WT and Il23p19−/− mice received an intra-plantar (i.pl.) injection of saline, a GM-CSF, b TNF, or c CCL17. Pain (incapacitance meter) was measured. Data are expressed as mean ± SEM; ac WT male mice (saline, n = 8; GM-CSF/TNF/CCL17, n = 10), Il23p19−/− male mice (GM-CSF/TNF, n = 10; CCL17, n = 15). For statistical analysis, a two-way ANOVA was used. ##P < 0.01, ####P < 0.0001, WT saline vs. WT GM-CSF, TNF, or CCL17. *P < 0.05, **P < 0.01, ***P < 0.001, WT GM-CSF, TNF, or CCL17 vs. Il23p19−/− GM-CSF, TNF, or CCL17, respectively

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