Fig. 5

IL-23 is required for GM-CSF-, TNF-, and CCL17-driven inflammatory pain. WT and Il23p19^−/− mice received an intra-plantar (i.pl.) injection of saline, a GM-CSF, b TNF, or c CCL17. Pain (incapacitance meter) was measured. Data are expressed as mean ± SEM; a–c WT male mice (saline, n = 8; GM-CSF/TNF/CCL17, n = 10), Il23p19^−/− male mice (GM-CSF/TNF, n = 10; CCL17, n = 15). For statistical analysis, a two-way ANOVA was used. ^##P < 0.01, ^####P < 0.0001, WT saline vs. WT GM-CSF, TNF, or CCL17. *P < 0.05, **P < 0.01, ***P < 0.001, WT GM-CSF, TNF, or CCL17 vs. Il23p19^−/− GM-CSF, TNF, or CCL17, respectively