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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: Overexpression of MIG-6 in the cartilage induces an osteoarthritis-like phenotype in mice

Fig. 4

Twelve-month-old Mig-6over/over male mice develop OA-like cartilage degeneration. Toluidine blue-stained sections of the knee joints from 12-month male control (a) and Mig-6over/over (b) mice were evaluated for cartilage damage following the OARSI histopathological scale on two quadrants of the knee: MFC, medial femoral condyle; MTP, medial tibial plateau. OARSI-based cartilage degeneration scores are significantly higher in the MFC and MTP of Mig-6-overexpressing mice, corresponding to the increased damage observed histologically (c). Data analyzed by two-way ANOVA with Bonferroni’s multiple comparisons test. Individual data points presented with mean ± SEM. All scale bars= 100 μm. N = 9 mice/group

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