| Intervention (n = 103) | Control (n = 86) |  |  |
---|---|---|---|---|
 | Mean (SD) | Mean (SD) | t†| p |
Pain intensity# | ||||
 Baseline | 24.37 ± 20.31 | 24.42 ± 19.65 | − 0.017 | 0.986 |
 Week 24 | 16.18 ± 15.94 | 23.47 ± 17.11 | − 2.793 | 0.006# |
 Week 48 | 13.62 ± 11.28 | 19.64 ± 16.83 | − 2.550 | 0.012# |
F‡ | 7.072 | 2.085 |  |  |
p | 0.001* | 0.131 | Â | Â |
Joint stiffness# | ||||
 Baseline | 24.03 ± 24.73 | 25.00 ± 25.37 | − 0.266 | 0.791 |
 Week 24 | 10.53 ± 12.49 | 19.62 ± 19.88 | − 3.376 | 0.001# |
 Week 48 | 9.77 ± 14.19 | 17.57 ± 21.36 | − 2.611 | 0.010# |
F‡ | 13.374 | 0.945 |  |  |
p | < 0.001* | 0.394 |  |  |
Lower limb muscle strength | ||||
 Baseline | 12.03 ± 5.09 | 12.27 ± 4.29 | − 0.350 | 0.727 |
 Week 24 | 9.61 ± 2.43 | 11.34 ± 3.66 | − 3.583 | < 0.001# |
 Week 48 | 10.29 ± 3.70 | 11.06 ± 2.79 | − 1.442 | 0.151 |
F‡ | 19.441 | 3.565 |  |  |
p | < 0.001* | 0.034* |  |  |
Balance | ||||
 Baseline | 2.95 ± 0.29 | 2.03 ± 0.22 | − 0.775 | 0.439 |
 Week 24 | 1.26 ± 0.13 | 1.60 ± 0.19 | − 4.747 | < 0.001# |
 Week 48 | 1.11 ± 0.12 | 1.22 ± 0.15 | − 2.576 | 0.011# |
F‡ | 13.847 | 6.687 |  |  |
p | < 0.001* | 0.002* |  |  |