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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: Ezh2-mediated epigenetic modification is required for allogeneic T cell-induced lupus disease

Fig. 1

Dependence of cGVHD-associated autoimmunity on CD4+ T cell Ezh2. bm12 mice (5 mice/group) were injected ip with 1 × 107 negatively selected CD4+ T cells from C57BL/6 (WT) or B6.CD4.Ezh2-KO (Ezh2) mice. Mouse sera were collected weekly. Total IgG and autoantibodies against dsDNA and chromatin were analyzed by ELISA [16, 19]. Data are representative of four repeats. Error bars show standard deviations. Student’s t test, *p < 0.05; **p < 0.01

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